[5] Luo W, Ma L, Wen Q, Wang N, Zhou MQ, Wang XN. Analysis of the interindividual conservation of T cell receptor alpha- and beta-chain variable regions gene in the peripheral blood of patients with systemic lupus erythematosus. Clin Exp Immunol. 2008 Dec;154(3):316-24. doi: 10.1111...
However, both C beta and C gamma sterile transcripts could be detected from the same bone marrow cell population isolated from RAG-1 gene deficient mice. Therefore, the expression of TCR genes can initiate at the earliest stages of T cell development, prior to exposure to the thymic ...
[8]CHAPUIS A G, EGAN D N, BAR M, et al. T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant[J]. Nat Med, 2019, 25(7): 1064-1072. [9]BLÜTHMANN H, KISIELOW P, UEMATSU Y, et al. T-...
compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cel...
T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoi...
immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T...
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, wh
Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature. 1993;362(6418):68–70. Article PubMed CAS Google Scholar Cheng MH, Zhang S, Porritt RA, Noval Rivas M, Paschold L,...
(with both the α and the beta β sequences) were considered, and sequences containing non-standard amino acids were removed. Duplicated TCR–pMHC were merged based on V/J gene usage and CDR3 sequence for both the α- and β-chain. The data analysis was done with Python (v.3.9.7) ...
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