Human TCR that incorporate CD3zeta induce highly preferred pairing between TCR alpha and beta chains following gene transfer [J]. J Immunol, 2008, 180(11): 7736-7746. [2] Cohen CJ,Li Y F, El-Gamil M, et al. Enhanced Antitumor Activity of T Cells Engineered to Express T-Cell Receptors...
W., and Hoffman, R. W. (2001). Structural analysis of TCR alpha and beta chains from human T-cell clones specific for small nuclear ribonucleoprotein polypeptides Sm-D, Sm-B and U1-70kDa: TCR comple- mentarity determining region 3 usage appears highly conserved. Scandinavian Journal of ...
[5] Luo W, Ma L, Wen Q, Wang N, Zhou MQ, Wang XN. Analysis of the interindividual conservation of T cell receptor alpha- and beta-chain variable regions gene in the peripheral blood of patients with systemic lupus erythematosus. Clin Exp Immunol. 2008 Dec;154(3):316-24. doi: 10.1111...
8、In the TCR similarity graph, each node (clonotype) is connected by edges to its K nearest-neighbor (KNN) nodes based on TCR similarity as assessed by the TCRdist measure, which scores sequence similarity in the pMHC-contacting CDR loops of the TCR alpha and beta chains (here K is an...
Paired analysis of TCR alpha and TCR beta chains at the single-cell level in mice Paired analysis of TCRα and TCRβ chains at the single-cell level in mice. J Clin Invest. 2011;121(1):288–95. Central↵ Dash P. , McClaren J. L. , Oguin T. H. 3rd . , Rothwell W. , Tod...
Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer. TCR gene therapy is adversely affected by newly formed TCRalphabeta heterodimers comprising exogenous and endogenous TCR chains that dilute expression of t... Z Sebestyén,E Scho...
A site in autonomic nerve pathways responsive to the adrenergic agents norepinephrine and epinephrine In general, alpha-1 receptors produce excitatory responses, and alpha-2 receptors produce inhibitory responses. See:beta-adrenergic receptor antigen receptor ...
consists of a ligand-specific alpha/beta heterodimer non-covalently associated with five invariant chains including the cd3 gamma/delta/eta and zeta subunits, all of which are required for efficient surface expression. t cell activation through the tcr induces cellular differentiation and/or...
The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma/delta/eta and zeta subunits, all of which are required for efficient surface expression. T cell activation through the TCR induces cell...
and Palacios,HV Boehmer 展开 摘要: Transfected T cell receptor (TCR) beta chain genes are expressed as homodimers on the surface of immature (Sci/ET27F) but not on mature (58 alpha-beta-) T cell lines which lack TCR alpha, gamma and delta chains. The homodimer on Sci/ET27F cells ...