Results The high levels of PD1-TCF1 CD8 T cells had a better PFS in NSCLC and ESCC cohorts. In the NSCLC cohort, high levels of PD1-TCF1 CD8 T cells were significantly and positively correlated with the number (P=0.0151) and size (P=0.0007) o...
PD1-TCF1+CD8+T细胞的高表达与更好的无进展生存期(PFS)和免疫治疗疗效有关;在NSCLC队列中,PD1-TCF1+CD8+T细胞的高表达还与三级淋巴结构的数量(P=0.0017)及相对面积(P=0.006)显著正相关。 结论 在NSCLC和ESCC患者中,PD1-TCF1+CD8+干细胞样记忆T细胞的高表达可能与良好的预后及免疫治疗疗效有关,并且在NSCLC...
如上图B所示,其中记忆样细胞Ly108+CXCR5-PD1+表现出很强的增殖特征,并且能够分化为各个亚群的细胞,并且如H图所示,这群细胞能够维持B细胞反应。这表示这群细胞具备干细胞样特征。有这样的特征那么是体内慢性抗原维持的原因吗? 4.TCF1+BC...
Objective To investigate the impact of PD1-TCF1 CD8 stem-like memory T cells on immunotherapy prognosis and tertiary lymphoid structure in tumors. Methods Pathological tissue sections were collected from 33 patients treated with immunotherapy, 18 cases of NSCLC and 15 cases of ESCC. The expression ...
TCF1+PD1+CD8+ T cells were detected in the blood and tumor-infiltrating lymphocytes (TILs) of patients with melanoma, that clearance of such cells resulted in ineffective immunotherapy, and that the anti-tumor effect of ICB was dependent on the promotion of TCF1+PD1+CD8+ T cell ...
2. (a-c) CD4+ cells were pre-gated and frequency of CD69+, ICOS+, and PD1+ cells among CD4+FOXP3− Tcon or CD4+FOXP3+ Treg-cells was measured, as indicated. (d) CD4+ cells were pre-gated and frequency of CD44+CD62L− cells among CD4+FOXP3− Tcon cells was measured. (...
a. Detection of CD44loCD62L+ naïve TCRβ+GFP+CD8+ T cells in splenocytes from WT and Ctcf−/− mice, and further analysis of activation markers including CD25, CD69, PD1, and ICOS of naïve cells. b. Cell division of CTV-labelled naïve WT or Ctcf–/– CD45.2+GFP+CD8+...
However, reduced TCF1 expression was broader than this since it was also seen in non-exhausted T-cells such as the KLRG1 + CD127 + subset (panel ii) which showed only weak PD1 and TIM3 expression. The marked loss of Ki67 expression indicative of a loss of cell division The loss of ...
(1)GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancerFront ImmunolJanuary 3, 2025Yujing Xuan, Wenyi Yan, Ruimin Wang, Xibin Wang, Yu Guo, Huilin Dun, Ziyan Huan, Lihua Xu, Ruxia Ha...
(D) Representative flow cytometry plots comparing PD1, LAG3 and TIM3 expression between SIIN- and SIY-specific cells at 5 weeks. Naive population (gray) represents CD44- tetramer- CD8α+ T cells. Geometric mean fluorescence intensity (gMFI) for PD1, LAG3 and TIM3 is plotted over time for...