8月29日,Nature杂志在线发表了剑桥大学MRC实验室Michel Goedert组与Sjors H. W. Scheres组合作完成的一篇题为Structures of filaments from Pick’s disease reveal a novel tau protein fold论文,阐述了皮克病的tau蛋白纤维丝的冷冻电镜(Cryo-EM)结构,将为皮克病的治疗提供新的方案和见解。 在正常成年人脑中,有...
Tau is a candidate gene for chromosome 17 fron-totemporal dementia Poorkaj et al. (1998) Ann Neurol 43: 815–825 Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17 Hutton et al. (1998) Nature 393: 702–705 Mutation in the tau gene in ...
【9】Barthelemy NR, et al (2016) Differential mass spectrometry profiles of tau protein in the cerebrospinal fluid of patients with Alzheimer’s disease, progressive supranuclear palsy, and dementia with lewy bodies.J Alzheimer’s Dis51:1033–1043. 【10】Meredith JE Jr, et al (2013) Characteriz...
Mutations in the gene that encodes the tau protein are known to result in neurodegenerative conditions like frontotemporal dementia, while in Alzheimer's disease the protein accumulates and becomes toxic. But the exact role of the tau protein in these diseases has remained a mystery. 为了帮助解决...
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The most common type of dementia is the Alzheimer’s disease (AD) [1], which is neuropathologically characterized by accumulated amyloid-β (Aβ) peptide protein and intraneuronal tangles of hyperphosphorylated micro tubule-associated protein tau [2]. The number of dementia patients has been ...
β-淀粉样肽异常沉积形成淀粉样斑块（amyloid plaques），tau蛋白高度磷酸化且异常聚集形成神经原纤维缠结 (neurofibrillary tangles)，这些都是起始之后数年痴呆（dementia）状态的内在病理变化。通过正电子发射断层扫描（positron emission tomography，简称PET）对淀粉样肽和tau蛋白进行同位素放射性示踪（radiotracers），每位...
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