doi:10.1016/j.ddmec.2005.11.008Jürgen GötzLars M. IttnerDella C. DavidDrug Discovery Today Disease MechanismsGotz J, Ittner LM, David DC. 2004. Role of the protein tau in Alzheimer's disease. Nerv Syst 4:395-399.
https://www.youtube.com/watch?v=A_tD92C1CFc Eckhard Mandelkow: Role of Tau protein in Alzheimer Disease and neurodegenerative tauopathies 订阅号:灵音悠扬 生物 科普 知识 科学科普 奥茨海默 becomequantum发消息 地球是圆的,外星人有很多,永动机已经被造出来了...
BC Das,S Pradhan,DP Ojha,A Das,NS Hosmane,S Das 摘要: Amyloid-β peptide (Aβ) and tau protein deposits in the human brain are the pathological hallmarks of Alzheimer’s disease (AD). Tau is a class of proteins that are abundant in nerve cells and perform the function of stabilizing...
Proteinopathy in neurodegenerative diseases is typically characterized by deteriorating activity of specific protein aggregates. In tauopathies, including Alzheimer’s disease (AD), tau protein abnormally accumulates and induces dysfunction of the affected neurons. Despite active identification of tau modificati...
Bou Samra E, Buhagiar-Labarchede G, Machon C, Guitton J, Onclercq-Delic R, Green MR, Alibert O, Gazin C, Veaute X, Amor-Gueret M (2017) A role for tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival. Nat Commun 8:693. https://doi.org...
protein tauAlzheimer’s diseaseneurodegenerative diseasesynaptic dysfunctionAβ-peptidestau-imagingOne of the most commonly known chronic neurodegenerative disorders, Alzheimer’s disease (AD), manifests the common type of dementia in 60–80% of cases. From a clinical standpoint, a patent cognitive ...
Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are the most prevalent pathologies in the elderly. Both pathologies have an increasing trend, but while in AD this increase is mainly due to the gradual aging of the population, in T2DM it also depends on a sedentary lifestyle ...
Collectively, our data implicate proteolysis of tau as an important pathway mediating tau degradation and neurotoxicity in vivo. 展开 关键词: Tauopathies Protein degradation Proteolysis Drosophila DOI: 10.1007/s12031-014-0314-7 被引量: 10 年份: 2015 ...
we wanted to examine its properties in a model for Alzheimer's disease, a neurological disorder of great significance. One of the hallmarks of Alzheimer's disease, besides extracellular plaque formation, is the intra-neuronal accumulation of hyper-phosphorylated tau protein that leads to tau aggregat...
Alzheimer’s disease CVD: Cardiovascular disease DAMP: Danger-associated molecular pattern HSF1: Heat shock transcription factor HSP: Heat shock proteins HSPB5: αB-crystallin IL: Interleukin MS: Multiple sclerosis NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells ...