Journal of Applied BiomedicineQuadros A, Ophelia IW, Ghania AG, Role of tau in Alzheimer's dementia and other neurodegenerative diseases, J. Appl. Biomed., 5,2007,1-12.Quadros A, Ophelia I W, Ghania A G. Role of tau in Alzheimer's dementia and other neurodegenerative diseases. J. Appl...
The identification of tau protein as a major constituent of neurofibrillary tangles spurred considerable effort devoted to identifying and validating pathways through which therapeutics may alleviate tau burden in Alzheimer’s disease and related tauopat
Alzheimer’s disease (AD) is a globally prevalent form of dementia that impacts diverse populations and is characterized by progressive neurodegeneration and impairments in executive memory. Although the exact mechanisms underlying AD pathogenesis remain unclear, it is commonly accepted that the aggregation...
Journal of Molecular Neuroscience (2022) 72:1929–1951 https://doi.org/10.1007/s12031-022-02047-1 Role of Chemokines in the Development and Progression of Alzheimer's Disease Jakub Wojcieszak1,2 · Katarzyna Kuczyńska1 · Jolanta B. Zawilska1 Received: 16 May 2022...
Cell fate and function are determined by integration of the cell’s molecular composition with its metabolic and signaling activity. Recent advances in single-cell genomic technologies have provided an unprecedented amount of data on the RNA, protein, and chromatin states of cells within tissues (Gri...
Aβ and tau are AD biomarker proteins that can be used to diagnose mid-stage cognitive impairment rather than early Alzheimer’s disease [10], [23]. Meanwhile, advanced AD diagnosis can be improved by detecting PACAP-38 levels following the onset of headache or migraine in patients with early...
Astrocytes and manganese in some neuropathological conditions: focus on Alzheimer’s disease (AD) and chronic hepatic encephalopathy (HE) Astrocytes play a critical role in the progression and outcome of neuropathological processes by reducing neural damage and promoting the revascularization of the ...
Alzheimer’s disease (AD) is a progressive neurogenerative disorder manifested by gradual memory loss and cognitive decline due to profound damage of
Alzheimer's Disease (AD) patients are more likely to experience epileptic seizures, and cognitive impairment is a frequent comorbidity in patients with epilepsy. Emerging findings indicate a common link between epilepsy and AD, however our understanding of the pathological changes shared between these ...
By 2030, an estimated one million Canadians will be living with Alzheimer's or some other neurocognitive disorder. So it's a race against time as researchers around the world work to identify effective treatments. In that race, some are pinning their hopes on tau, aproteinwhose accumulation i...