Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated loss of synapses and neurons, resultin
Therapies for Alzheimer disease in clinical trials are gradually shifting from amyloid-β (Aβ)-targeting to tau-targeting approaches. Early anti-tau therapies were based mainly on inhibition of kinases or tau aggregation, or on stabilization of microtubules, but most of these approaches have been ...
Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibitMAPTexpression with a tau-targeting antisense oligonucleotide (MAPTRx) and reduce tau levels in patients with mild AD. A randomized...
doi:10.1016/j.jalz.2018.06.2362Dai, ChunlingHU, WenLiu, FeiGong, Cheng-XinIqbal, KhalidElsevier ScienceAlzheimer's and Dementia
Tau deposition in the brain is a pathological hallmark of many neurodegenerative disorders, including Alzheimer’s disease (AD). During the course of these tauopathies, tau spreads throughout the brain via synaptically-connected pathways. Such propagation of pathology is thought to be mediated by tau...
Phosphorylation is one of the most prevalent post-translational modifications found in aggregated tau isolated from Alzheimer’s disease (AD) patient brains. In tauopathies like AD, increased phosphorylation or hyperphosphorylation can contribute to micr
For instance, in Alzheimer’s disease the slow rate of AHN could be enhanced by taking qNSCs out of slumber to improve cognitive deficits whereas AHN could be slowed down by promoting quiescence in other diseases, like epilepsy, to avoid an early depletion of the NSC pool. In addition ...
microrna-425-5ppromotestauphosphorylationandcellapoptosisinalzheimeracutesdisease 系统标签: tauapoptosisphosphorylationalzheimertargetingmicrorna Vol.:(0123456789)13 JournalofNeuralTransmission https://doi/10.1007/s00702-019-02134-5 NEUROLOGYAND PRECLINICALNEUROLOGICALSTUDIES-ORIGINALARTICLE MicroRNA‑425‑5ppromo...
The pathogenesis of intracellular neurofibrillary tangles, a hallmark of tauopathies, is initiated by hyperphosphorylated tau protein isoforms that cause neuronal death and lead to diseases like Alzheimer's, Parkinson's disease, frontotemporal dementia, and other complex neurodegenerative diseases. Current ...
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated loss of synapses and neurons, resulting in cognitive deficits and eventually deme