阿尔茨海默病(Alzheimer′s disease, AD)是一种起病较为隐匿且进行性发展的神经退行性疾病,其主要临床特征是认知功能障碍和行为的改变。AD的病理学特征主要是β-淀粉样蛋白(β-amyloid, Aβ)的沉积及tau蛋白过度磷酸化导致神经原纤维缠结(neurofibrillary tangles, NFT)形成。过往研究发现,NFT的形成与神经元功能障碍...
Alzheimer's disease is a severe neurodegenerative disease characterized by the deposition of neuritic plaques on neuronal membranes and the formation of neurofibrillary tangles within neurons. Several proteins, such as amyloid beta and tau, play major roles in the pathophysiology and progression ...
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Alzheimer's disease is characterized by abnormal elevation of Aβ peptide and abnormal hyperphosphorylation of the tau protein. The "amyloid hypothesis," w... SA Small,K Duff - 《Neuron》 被引量: 1089发表:...
Research on the molecular pathogenesis of Alzheimer's disease (AD) has made great strides over the last decade. This progress is the result of protein chemical analysis of two extracellular and intracellular fibrillary lesions in AD brain conducted during the 1980s, which identified β-amyloid prote...
阿尔茨海默病(Alzheimer′s disease, AD)是一种起病较为隐匿且进行性发展的神经退行性疾病,其主要临床特征是认知功能障碍和行为的改变。AD的病理学特征主要是β-淀粉样蛋白(β-amyloid, Aβ)的沉积及tau蛋白过度磷酸化导致神经原纤维缠...
随着年龄增长,人们有时会发生记忆衰退的情况。忘记人生中重要的日期、突然想不起亲人的名字、出门后却遗忘自己的目的地...这些事件往往是阿尔茨海默氏病(Alzheimer's disease,AD)的早期迹象。 随着全球人口老龄化日益严重,目前全球约有近5,000万人患有AD,并且发病率也在不断增加,逐步成为严重威胁人类健康的疾病之一...
Patients with Alzheimer’s disease (AD) present with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years, the prevailing view of AD pathogenesis has been that changes in Aβ precipitate the disease process and initiate a...
Abstract: Alzheimer's disease(AD)is a neurodegenerative disease with memory and recognition defects and anxiety.The senile plaque formed by amyloid0-protein(A0)and neurofibrillary tangles containing tau protein are the main pathological characteristics.Tau hypothesis is one of the most accepted AD ...
Previous studies have reported that age modifies the distribution and burden of tau (and, to a lesser extent, amyloid) pathology in sporadic Alzheimer's disease (AD). Here we present preliminary baseline amyloid and tau PET results from the Longitudinal Early㎡nset Alzheimer's Disease Study (...
阿尔茨海默病(Alzheimer′s disease, AD)是一种起病较为隐匿且进行性发展的神经退行性疾病,其主要临床特征是认知功能障碍和行为的改变。AD的病理学特征主要是β-淀粉样蛋白(β-amyloid, Aβ)的沉积及tau蛋白过度磷酸化导致神经原纤维缠结(neurofibrillary tangles, NFT)形成。过往研究发现,NFT的形成与神经元功能障碍...