Patients with Alzheimer’s disease (AD) present with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years, the prevailing view of AD pathogenesis has been that changes in Aβ precipitate the disease process and initiate a...
Previous studies have reported that age modifies the distribution and burden of tau (and, to a lesser extent, amyloid) pathology in sporadic Alzheimer's disease (AD). Here we present preliminary baseline amyloid and tau PET results from the Longitudinal Early㎡nset Alzheimer's Disease Study (...
increasingly recognized as an important contributor to Alzheimer's disease (AD) pathogenesis. As a part of the innate immune system, the complement cascade enhances the body's ability to destroy and remove pathogens and has recently been shown to influence Alzheimer's associated amyloid and tau ...
检索策略采用主题词与自由词相结合的方式,核心检索词包括“Alzheimer's disease、disease-modifying therapy、amyloid-beta、tau protein、clinical trials、randomized controlled trials、therapeutic efficacy、safety evaluation、阿尔茨海默病、疾病修饰治疗、β-淀粉样蛋白、tau蛋白、临床试验、随机对照试验、疗效评估、安全性...
more recently new light has been shed on their possible interactions and synergistic effects in Alzheimer's disease. Here, we review novel findings that have shifted our understanding of the role of tau in the pathogenesis of Alzheimer's disease towards being a crucial partner of amyloid-β. As...
文章发表在《中国神经再生研究(英文)》杂志2026年2期。 文章来源:Sha S, Ren L, Xing X, Guo W, Wang Y, Li Y, Cao Y, Qu L (2026) Recent advances in immunotherapy targeting amyloid-beta and tauopathies in Alzheimer’s disease. Neural Regen Res 21(2):577-587....
Alzheimer’s disease (AD) is a fatal disease that threatens the quality of life of an aging population at a global scale. Various hypotheses on the etiology of AD have been developed over the years to guide efforts in search of therapeutic strategies. In
AloisAlzheimer是一位德国科学家,他在1907年发现了一位已故病人大脑中神经元的纠结束。tau(微管蛋白相关单位)通常位于神经元轴突中,在那里它稳定微管。陶蛋白病变,如AD,其特征是含有高磷酸化陶蛋白纤维的神经纤维缠结。成人大脑中tau有六种亚型:三种具有四个重复单位(4r),三种具有三个重复单位(3r)。k18是人类tau...
姜黄素优化提取物对阿尔茨海默病转基因小鼠β-淀粉样蛋白(Aβ)及磷酸化Tau蛋白的调控作用研究 《Current Alzheimer Research》:Retraction Notice: Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer's Transgenic Mice...
Barthélemy, N.R., Li, Y., Joseph-Mathurin, N.et al.A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease.Nat Med26, 398–407 (2020). https://doi.org/10.1038/s41591-020-0781-z ...