Understanding the role of Tau protein aggregation in the pathogenesis of Alzheimer's disease is critical for the development of new Tau-based therapeutic strategies to slow or prevent dementia. We tested the hy
In several diseases of the brain, long fibers of protein form, and eventually become tangled to form dense bodies known as “plaque” or “aggregates.” Alzheimer’s disease, which causes dementia, is one well-known example, in which the plaque usually consists of faulty variants of two prot...
It is this pathology which is characteristic of Alzheimer disease (AD) and other tauopathies. To date, the most established and the most compelling cause of dysfunctional tau in AD and other tauopathies is the abnormal hyperphosphorylation of tau. The abnormal hyperphosphorylation not only results in...
In Alzheimer’s disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well established, but imperfect. We investigate whether cerebrospinal fluid (CSF) biomarkers of biological processes (vascular, synaptic, and axonal integrity, neuroinflammation, neurotrophic fa...
Alzheimer’s disease,”Brendan P. Lucey, MD,assistant professor of neurology department and director of the sleep medicine section at Washington University School of Medicine, toldHealio Psychiatry. “Our paper investigated this second question:...
Alterations of brain and cerebellar proteomes linked to Ab and tau pathology in a female triple-transgenic murine model of Alzheimer's disease. Cell Death Dis 1, e90.Ciavardelli D, Silvestri E, Del Viscovo A, et al. Alterations of brain and cerebellar proteomes linked to Ab and tau ...
Alzheimer's diseaseautophagygranulovacuolar degenerationlysosomesmitochondriamitophagyParkinPINK1PRKNtauIntroduction: The cytoprotective PTEN-induced kinase 1 (PINK1)-parkin RBR E3 ubiquitin protein ligase (PRKN) pathway selectively labels damaged mitochondria with phosphorylated ubiquitin (pS65-Ub) for their ...
An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and, consequently, clinical deterioration. In vitro evidence su...
Extensive human studies and animal models show that chronic immune system stimulation involving microglia, inflammasome, complement activation, synthesis of cytokines, and reactive oxygen species exacerbates neurodegeneration in Alzheimer’s disease (AD)
PREDICTING TAU PATHOLOGY PROGRESSION IN ALZHEIMER’S DISEASE BY MATHEMATICAL SIMULATION: FURTHER RESULTS AND PRIORITISATION OF MODIFICATIONS FOR FURTHER IMPROVEMENTSdoi:10.1016/j.jalz.2019.06.3719Jean-Paul SoucyFatameh MohammadiValentine HortelanThomas Boulier...