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Neurofibrillar protein aggregates containing tau are one of the major hallmarks of Alzheimer's disease (AD). In normal cells, tau stabilizes axonal microtubules, which are the tracks for intracellular traffic. In AD, tau becomes abnormally phosphorylated, aggregates into paired helical filaments and...
The microtubule-associated protein tau and amyloid-β (Aβ) are key players in Alzheimer's disease (AD). Aβ and tau are linked in a molecular pathway at the post-synapse with tau-dependent synaptic dysfunction being a major pathomechanism in AD. Recent work on site-specific modification of...
Progressive dementias like Alzheimer's Disease (AD) and other tauopathies are an increasing threat to human health worldwide. Although significant progress has been made in understanding the pathogenesis of these diseases using cell culture and mouse models, the complexity of these diseases has still ...
It is this pathology which is characteristic of Alzheimer disease (AD) and other tauopathies. To date, the most established and the most compelling cause of dysfunctional tau in AD and other tauopathies is the abnormal hyperphosphorylation of tau. The abnormal hyperphosphorylation not only results in...
阿尔茨海默病(Alzheimer disease,AD),又叫老年性痴呆,是一种中枢神经系统变性病,起病隐袭,病程呈慢性进行性,是老年期痴呆最常见的一种类型。 阿尔兹海默症多起病于老年期,潜隐起病,病程缓慢且不可逆,临床上以智能损害为主。病理改变主要为皮质弥漫性萎缩,沟回增宽,脑室扩大,神经元大量减少,并可见老年斑SP,神经...
阿尔茨海默病(Alzheimer′s disease, AD)是一种起病较为隐匿且进行性发展的神经退行性疾病,其主要临床特征是认知功能障碍和行为的改变。AD的病理学特征主要是β-淀粉样蛋白(β-amyloid, Aβ)的沉积及tau蛋白过度磷酸化导致神经原纤维缠...
For early detection of Alzheimer’s disease, it is important to find biomarkers with predictive value for disease progression and clinical manifestations, such as cognitive decline. Individuals can now be profiled based on their biomarker status for Aβ4
阿尔茨海默病(Alzheimer disease,AD),又叫老年性痴呆,是一种中枢神经系统变性病,起病隐袭,病程呈慢性进行性,是老年期痴呆最常见的一种类型。主要表现为渐进性记忆障碍、认知功能障碍、人格改变及语言障碍等神经精神症状,严重影响社交、职业与生活功能。 AD的病因及发病机制尚未阐明,特征性病理改变为β淀粉样蛋白沉积形...
阿尔茨海默病(Alzheimer’s disease,AD)又称老年性痴呆。是以淀粉样蛋白(amyloid-β,Aβ)沉积和Tau蛋白形成的神经纤维缠结为主要病理特征的进行性中枢神经系统退行性疾病。其主要临床表现为短期记忆退化、反应迟钝、说话重复、理解及表达能力下降。根据世界卫生...