在TAS2R14的N端加LargeBit,与Ggust或Gi结合。经过验证,AA和FFA均为TAS2R14的强效激动剂。 利用相似的方法解出了TAS2R14与AA,FFA,化合物18.1结合的结构。 在不同的结构中,TAS2R14展示出相似的构象。 Cholesterol and aristolochic acid binding in TAS2R14 通过解析TAS2R14的cryo-EM结构,得到了TAS2R14上...
TAS2R14的激动剂如奎宁和咖啡因,对气道平滑肌松弛有显著影响,而另一激动剂药物诺斯卡平可以抑制IGE依赖性肥大细胞的活化,因此TAS2R14作为呼吸系统疾病的治疗靶点具有很大的潜力。 虽然目前人类已经解析了近200个独特的GPCR结构,对其激活及...
基因别名:T2R14; TAS2R14; TRB1 UniProt ID:(Human) Q9NYV8 Entrez Gene ID:(Human) 50840 功能 G-protein coupled receptor activitytaste receptor activitybitter taste receptor activitytransmembrane signal receptor 参与通路 detection of chemical stimulus involved in sensory perception of bitter tasteG-prot...
苦,作为一种基本的味觉,一直以来都是人类对食物的重要感知。在舌头上有许多不同的味蕾,其中一种名为TAS2R14的受体,是专门负责识别和感受苦味的。它的工作原理和激活机制是科学家们长期研究的焦点,这对于理解食物的口感,甚至疾病的预防和治疗都有深远的影响。
英文名称: TAS2R14 agonist-2 总访问: 48 国产/进口: 进口 半年访问: 4 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg 最后更新: 2024-11-4 货号: HY-153265 CAS 号: 2883007-69-8 参考报价: 2695; 2450; 3900; 8200 立即询价 电话咨询 ...
TAS2R14 cDNA克隆 货号产品名称Method规格价格货期 CDS-H12915-1 pDonR223-TAS2R14 GateWay 2ug/0.5ml ￥800 现货 CDS-H12915-2 pMD18-T-TAS2R14 TA克隆 2ug/0.5ml ￥800-1500 1-2周TAS2R14 重组病毒 货号产品名称Method规格价格货期 CDS-H12915-11 rAd-TAS2R14 重组腺病毒 10^10cfu/支 ￥...
Here we present cryogenic electron microscopy structures of TAS2R14 in complex with aristolochic acid, flufenamic acid and compound 28.1, coupling with different G-protein subtypes. Uniquely, a cholesterol molecule is observed occupying what is typically an orthosteric site in class A G-protein-...
Bitter taste receptors, particularly TAS2R14, play central roles in discerning a wide array of bitter substances, ranging from dietary components to pharmaceutical agents1,2. TAS2R14 is also widely expressed in extragustatory tissues, suggesting its extra roles in diverse physiological processes and...
Human TAS2R14 VLP information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.