近日,上海科技大学刘志杰、华甜,山东大学孙金鹏及上海交通大学附属第九人民医院杨驰组成的联合团队发表在Nature的论文报道了人源苦味受体TAS2R14在配体识别和受体激活方面的研究成果。TAS2R14是识别苦味分子范围最广的受体,在人支气管中的表...
5月22日,上海科技大学iHuman研究所、生命科学与技术学院华甜和刘志杰团队,联合山东大学基础医学院孙金鹏团队及上海交通大学医学院第九人民医院杨驰团队在《自然》(Nature)上以“文章加速预览(Accelerated Article Preview,AAP)”形式在线发表了题为“Bitter taste TAS2R14 activation by intracellular tastants and cholest...
Nature volume 631, pages 459–466 (2024)Cite this article 14k Accesses 19 Altmetric Metrics details Abstract Bitter taste receptors, particularly TAS2R14, play central roles in discerning a wide array of bitter substances, ranging from dietary components to pharmaceutical agents1,2. TAS2R14 is ...
doi:10.1038/s41586-024-07569-9Xiaolong HuWeizhen AoMingxin GaoLijie WuYuan PeiShenhui LiuYiran WuFei ZhaoQianqian SunJunlin LiuNature Publishing Group UKNature
Dehua Yang& Jia Duan Cell Research34,735–738 (2024)Cite this article 2366Accesses 18Altmetric Metrics Dear Editor, Bitter taste perception serves as a vital defense mechanism against potentially harmful substances in humans. Within the subfamily of bitter taste receptors, known as TAS2Rs, there ar...
5月22日,上海科技大学iHuman研究所、生命科学与技术学院华甜和刘志杰团队,联合山东大学基础医学院孙金鹏团队及上海交通大学医学院第九人民医院杨驰团队在《自然》(Nature)上以“文章加速预览 (Accelerated Article Preview, AAP)”形式在线发...
5月22日,上海科技大学iHuman研究所、生命科学与技术学院华甜和刘志杰团队,联合山东大学基础医学院孙金鹏团队及上海交通大学医学院第九人民医院杨驰团队在《自然》(Nature)上以“文章加速预览(Accelerated Article Preview,AAP)”形式在线发表了...
Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonistCell signallingCryoelectron microscopydoi:10.1038/s41422-024-00995-4Lele TaoDongxue WangQingning YuanFenghui ZhaoYu ZhangTianyuan DuShiyi ShenH. Eric Xu
近日,上海科技大学刘志杰、华甜,山东大学孙金鹏及上海交通大学附属第九人民医院杨驰组成的联合团队发表在Nature的论文报道了人源苦味受体TAS2R14在配体识别和受体激活方面的研究成果。TAS2R14是识别苦味分子范围最广的受体,在人支气管中的...
Zhang YX, Wang X, Li X, Peng S, Wang SF, Huang CZ, et al. Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies. Sci Rep-Uk 2017;7. https://doi.org/ 10.1038/s41598-017-11720-0....