其中,TAM-SPP1在血管生成、分解代谢和合成代谢途径中富集。这表明TAM-SPP1通过激活代谢途径利用TME中有限的营养物质,可能在调节胶质瘤TME内的代谢和血管生成中发挥重要作用(图2g-h)。最后作者利用507低级别胶质瘤患者的转录组测序数据,证实了TAM-AIF1和TAM-SPP1相关的标记物与患者生存结果较差相关,而在TAM-CCL3亚...
其中发现一组以SPP1高表达、免疫抑制分子程序上调、集落刺激因子-1受体 (CSF1R) 转录水平显著降低为特征的SPP1高度表达巨噬细胞亚群 (SPP1hi-TAM)随疾病进展显著增加,此外,体外培养结果显示这群细胞以密度依赖的方式显著抑制T细胞增殖,且导致IFN-γ+TNF-α+ CD8+ T细胞的频率显著降低,提示SPP1hi-TAM可能是mCRPC...
Cell-cell communication analysis implied that SPP1+ TAM populations may employ SPP1 signaling to activate metastasis-related ECs. In vitro and in vivo studies, we demonstrated that SPP1hi TAMs enhanced tumor intravasation and metastasis in HNSCC in a manner dependent on the secretion of SPP1, ...
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma 来自 Nature 喜欢 0 阅读量: 50 作者:W Jiashun,S Yi,LGL Guozhong 摘要: Macrophages are heterogeneous cells that play multifaceted roles in cancer progression and metastasis....
研究人员利用单细胞RNA测序技术,通过对处于不同疾病阶段的前列腺癌患者肿瘤样本活检的分析发现,SPP1高表达的肿瘤相关巨噬细胞 (SPP1hi-TAM)亚群随疾病进展而富集。并通过腺苷信号通路抑制CD8+ T细胞活性,最终导致免疫治疗的耐药性。研究进一步表明,阻断腺苷A2A受体(A2AR)不仅可以有效降低SPP1hi-TAMs的免疫抑制作用,还...
Hares in the sandy ecosystem of the Mediterranean coastal plain in Israel consume pods of the widespread desert plantRetama raetam. The aim of this study was to explore some of its qualities as a dispersal agent of such an important component of the vegetation of Mediterranean arid habitats. Al...