Expansion of activated memory CD4þ T cells affects infectivity of CCR5-tropic HIV-1 in humanized NOD/SCID/JAK3null mice. PLoS One 2013;8:e53495.Terahara K, Ishige M, Ikeno S, Mitsuki YY, Okada S, Kobayashi K, et al. Expansion of activated memory CD4+ T cells affects infectivity of...
B cells can differentiate into the antibody-secreting cells, plasma cells, whereas the crucial signals that positively control the entry into the pathway t... K Agematsu,H Nagumo,Y Oguchi,... - 《Blood》 被引量: 533发表: 1998年 Memory CD4 T cells emerge from effector T-cell progenitors ...
Tumor-resident CD8+ T cells display a quiescent effector/memory phenotype that is maintained in part by infiltrating CD4+ CD25+ Foxp3+ T-suppressor cells. Intratumoral delivery of IL-12, in contrast, can restore cytotoxic function to tumor-associated CD8+ T cells and induce the apoptotic death...
Methods Here, using magnetic beads and fluorescence- activated cell sorting, we extensively phenotype the Tck effector cells and conclude that effector function resides within the CD4+CD45RO+, CCR7-, CD49dhigh population, and that these cells are derived from the effector memory CD4+ T cells ...
Mitochondrial respiration rate in memory CD4 + T-cells derived from IR was comparable to that of C at basal state, however, after stimulation IR failed to reach the values of uninfected subjects. INR had the lowest mitochondrial respiration rate both at basal state and aft...
ACTIVATED/MEMORY BUT NOT NAiVE CD4+ T-CELLS INDUCE COLITIS IN ATHYMIC NU/NU MICE: : Introduction: We have previously reported that transfer of naive CD4+CD45RBhgh T-cells into athymic nude mice fails to induce colitis whereas transfer of these same T-cells into RAG-1-/- recipients induces...
MiR-21 mediates survival of activated memory CD4+ T-cells.Katarzyna SmigielskaCzepielAnke van den BergPytrick JellemaIzabella SlezakProchazkaHenny MaatHilda van den BosRoelof Jan van der LeiJoost KluiverElisabeth BrouwerAnne Mieke H. Boots
mice. However, the conversion of CD4+ T cells to an activated effector memory phenotype, with a high percentage of cells showing Ki-67 expression, occurred in both hNOJ (IR+) and hNOJ (IR?) mice, probably as a result of lymphopenia-induced homeostatic expansion. Furthermore, when hNOJ ...
T cellsSurvival analysisCeRNA networkLiver cancer is one of the most common malignant tumors in the world. T cell-mediated antitumor immune response is the basis of liver cancer immunotherapy.#To screen and analyze the RNAs associated with activated memory CD4 T cells and CD8 T cells in liver ...
T cells generate antigen-specific immune responses to their cognate antigen as a hallmark of adaptive immunity. Despite the importance of antigen-specific T cells, here we show that antigen non-related, bystander memory-like CD4 T cells also significantly contribute to autoimmune pathogenesis. Transcri...