我们分析并可视化了肝癌的主要细胞类型,其中传统的CD4+ T细胞占HCC免疫微环境的很大比例。 2.CD4+tconv相关基因和lncRNAs的鉴定和功能富集 我们在两个平台上从GSE140228中获得了CD4+Tconv相关基因,并确定了478个交叉的CD4+Tconv相关基因。在交叉的CD4+Tconv相关基因的基础上,通过GO和KEGG通路富集分析,明确了这些基...
6、原始的或天然T细胞(Virgin or Natural T cells),他们和抗原接触后分化成效应T细胞和记忆T细胞; 7、记忆T细胞(Memory T cell,Tm),有记忆特异性抗原刺激的作用。T细胞在体内存活的时间可数月至数年。其记忆细胞存活的时间则更长。 其中,Th细胞又被称为CD4+细胞,因为其在表面表达CD4(cluster of differentiation ...
Expansion of Activated Memory CD4+ T Cells Affects Infectivity of CCR5-Tropic HIV-1 in Humanized NOD/ SCID/JAK3null Mice. et al. Expansion of activated memory CD4+ T cells affects infectivity of CCR5-tropic HIV-1 in humanized NOD/SCID/JAK3null mice. PLoS One 8, e53495... Terahara,Kazu...
J. T cells, particularly activated CD4+ cells, maintain anti-CD20-mediated NK cell viability and antibody dependent cellular cytotoxicity. Cancer Immunol. Immunother. 71, 237–249 (2021). Bogen, B., Fauskanger, M., Haabeth, O. A. & Tveita, A. CD4+ T cells indirectly kill tumor cells...
Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells. BRODERICK L,YOKOTA SJ,REINEKE J,et al.Human CD4+ effector memory T cells persisting in the micr...
Memory-like CD4+ T cells had high expression of Ki-67, indicative of cell division, and CD5, a surrogate marker of TCR avidity, and produced the cytokines IFN-γ and IL-2. Pathway analysis revealed a differentiation trajectory associated with cellular activation and proinflammatory effector ...
Cancer immunology and immunotherapy are driving forces of research and development in oncology, mostly focusing on CD8~+ T cells and the tumor microenvironment. Recent progress highlights the importance of CD4~+ T cells, corresponding to the long-known fact that CD4~+ T cells are central players...
Treg cells have been also pointed out as one of the major reasons for the failure of immunotherapies. Counteracting Treg cells activity may significantly enhance clinical efficiency of therapeutic tumor vaccine. 展开 关键词: CD4+ T cell tumor immunity CD4+CD25+ regulatory T cell immmunotherapy ...
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema Gabriela D. García Nores, Catherine L. Ly, Daniel A. Cuzzone, Raghu P. Kataru, Geoffrey E. Hespe, Jeremy S. Torrisi, Jung Ju Huang, Jason C. Gardenier, Ira L. Savetsky, Matth...
Nagaraj, "CD4+ T cells suppress immune response to cancer: Novel targets for antitumor efforts," Expert Review of Clinical Immunology, vol. 8, no. 5... A Nelson,S Nair,S Nagaraj - 《Expert Rev Clin Immunol》 被引量: 3发表: 2012年 ...