We previously reported that there are three different copies of T-cell receptor β chain constant region (Cβ) genes in some rabbits, two of which are present on an ~ 16-kb and one on an ~6-kb Eco RI fragment. We also reported that one of the Cβ genes on the ~ 16-kb fragment...
In the predominant αβ TCR, the two disulfide-linked transmembrane α and β polypeptide chains each bear one N-terminal Ig-like variable (V) domain, one Ig-like constant (C) domain, a hydrophobic transmembrane region, and a short cytoplasmic region. T cell receptor genes The human T cell...
The T cell receptor beta chain (TCRB) repertoires of different CD4+T cell subsets (true naive, TN; central memory, CM; regulatory, Treg; and stem cell-like memory, Tscm) were examined using next generation sequencing technology in 14 recently diagnosed patients with type 1 diabetes (T1D) a...
Chimeric antigen receptor (CAR)-modified T cells have been developed by generating numerous tumor-targeting T cells. A CAR consists of an extracellular antigen-binding domain, a hinge domain, a transmembrane domain, intracellular domains with a costimulatory domain (such as 4-1BB and CD28), and ...
Residues of the variable region of the T-cell-receptor |[beta]|-chain that interact with S. aureus toxin superantigens The alpha beta T-cell antigen receptor (TCR) recognizes antigenic peptides in the context of self major histocompatibility complex (MHC) molecules. The spe... Y Choi,A He...
Protein Experimental Models Kits Other Keywords Epitope Single-cell analysis T-cell receptor repertoire Complementarity-determining region 3 TCR alpha TCR beta TCR diversity Unbiased repertoire Paired analysis Clonotype * Reagents occurring with supplier names are extracted and shared by CiteAb.Related...
Diversity of T cell receptor-α chain transcripts from hyperimmune alloreactive T cells 来自 Semantic Scholar 喜欢 0 阅读量: 34 作者: B Tjoa,DM Kranz 展开 摘要: Alloreactive T cells represent a relatively large fraction of the T cell population compared with the fraction of T cells ...
The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory response. Analysing the TCR repertoire may help to gain a bette
Signal intensity and feedback regulation are known to be major factors in the signaling events stemming from the T-cell receptor (TCR) and its various coreceptors, but the exact nature of these relationships remains in question. We present a mathematical
Chimeric-antigen-receptor (CAR) T-cell therapy for CD19-expressing B-cell malignancies is already widely adopted in clinical practice. On the other hand, the development of CAR-T-cell therapy for T-cell malignancies is in its nascent stage. One of the potential targets is CD26, to which ...