Although T cells are activated in INS during relapse, as indicated by an increased expression of interleukin (IL)-2 receptor, these cells have a decreased ability to proliferate. The T-cell receptor (TCR) plays an important role in signal transduction and T cell activation, with the TCR-zeta...
其表面存在的T细胞受体(T cell receptor, TCR)能够识别主要组织相容性复合体(major histocompatibility complex, MHC)呈递的抗原多肽,并将抗原结合信号转换为胞内酪氨酸磷酸化信号,引发下游信号通路来激活T细胞。在临床上,T细胞受体工程化T细胞(T cell receptor-engineered...
T-Cells are a subset of lymphocytes that play a large role in the immune response. The TCR (T-Cell Receptor) is a complex of integral membrane proteins that participates in the activation of T-Cells in response to the presentation of antigen.
In mice, tumour induced immune suppression has been associated with a decreased expression of the zeta-chain of the T cell receptor (TCR)-CD3 complex, and loss of mRNA for granzyme B. AIM: To compare the expression of TCR-zeta and granzyme B in lymphocytes infiltrating normal colonic mucosa...
一、CAR-T研究背景 CAR-T(Chimeric Antigen Receptor T cell)，即嵌合抗原受体(CAR)T细胞，是一种新的细胞疗法，从患者身上获取自体T细胞并进行基因修饰以表达嵌合抗原受体。这些受体由细胞外的scFv组成，该scFv被设计成与高特异性靶标结合，以及由共刺激结构和T细胞受体（TCR）zeta链组成细胞内部分[1,2]。这些修饰...
et al. Transfer of specificity by murine alpha and beta T-cell receptor genes. Nature 320, 232–238 (1986). CAS PubMed Google Scholar Tsang, J. Y. et al. Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. J. Clin. ...
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes ...
The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell. 1991;64:891–901. Article CAS PubMed Google Scholar Romeo C, Amiot M, Seed B. Sequence requirements for induction of cytolysis by the T cell antigen/...
αβT cellsare the sentinel players of the cellular adaptive immunity, combating foreign pathogens and cancer cells. Using the T-cell receptor (TCR), in conjunction with the co-receptor CD4 or CD8, they recognize antigenic peptides presented by the respectivemajor histocompatibility complex(pMHC) ...
Provided is a T-cell expressing a chimeric receptor, wherein the chimeric receptor specifically recognizes BCMA, and the endogenous TCR molecule and the endogenous MHC molecule are