T lymphocyte development is directed by a gene-expression program that occurs in the complex nucleoprotein environment of chromatin. This review examines basic principles of chromatin regulation and evaluates ongoing progress toward understanding how the chromatin template is manipulated to control gene expre...
Schluns, K., Lefrançois, L. Cytokine control of memory T-cell development and survival.Nat Rev Immunol3, 269–279 (2003). https://doi.org/10.1038/nri1052 Download citation Issue Date01 April 2003 DOIhttps://doi.org/10.1038/nri1052 ...
Engineered T cells are at the leading edge of clinical cell therapy. T cell therapies have had a remarkable impact on patient care for a subset of hematological malignancies. This foundation has mo...
Development and function of T cells in T cell antigen receptor/CD3 ζ knockout mice reconstituted with FcRIγ Engagement of α -β T cell receptors (TCRs) induces many events in the T cells bearing them. The proteins that transduce these signals to the inside of ce... Liu, C.-P.,Lin...
Changes in heat shock protein synthesis and heat sensitivity during mouse thymocyte development Heat shock protein synthesis was examined in mouse thymocytes at three stages of development: early embryonic thymocytes, which are CD4-CD8-, adult thymocy... DD Mosser,J Duchaine,L Bourget,... - 《...
Development of an Absolute Quantitative MS Method to Cover All CD3 ITAMs Phosphorylation of CD3 ITAMs has been detected in whole-cell lysate samples by mass spectrometry, but absolute quantitation is lacking (Goodfellow et al., 2015). Because of the large number of tyrosine sites in a TCR compl...
The development of TCRαβ and TCRγδ T cells comprises a step-wise process in which regulatory events control differentiation and lineage outcome. To clarify these mechanisms, we employed RNA-sequencing, ATAC–sequencing and ChIPmentation on well-defined thymocyte subsets that represent the continuum...
The development of TCRαβ and TCRγδ T cells comprises a step-wise process in which regulatory events control differentiation and lineage outcome. To clarify these mechanisms, we employed RNA-sequencing, ATAC–sequencing and ChIPmentation on well-defin
Targeting mitotic regulators as a strategy to fight cancer implies the development of drugs against key proteins such as Aurora A and B. Current drugs whic... M Carlos,T Raquel,LM José - 《Frontiers in Oncology》 被引量: 2发表: 2016年 Renal function, cytogenetic measurements, and sexual de...
25. Mice with conditionally depleted SATB1 from T cells display impaired T cell development accompanied with an autoimmune-like phenotype17,26,27. Moreover, SATB1 is also overexpressed in a wide array of cancers and is positively associated with increased tumor size, metastasis, tumor progression,...