In the thymus CD4 + helper cells and CD8αβ + cytotoxic cells are generated under tight MHC control. Besides intrathymic T cell generation, T cells are generated outside the thymus. Peripheral expansion of mature T cells, which may or may not be antigen driven, is a major source of ...
Immunology: T-cell development in the thymusNo Abstract available for this article.doi:10.1038/309583b0ShortmanKenNature Publishing Group UKNatureShortman, K. ( 1984 ) News and Views: Immunology: T-cell development in the thymus Nature . 309 , 583 ....
T cell development occurs in the thymus throughout life. Recent experimental findings show that the seeding of the thymus by multi-potent stem cells from the bone marrow is periodic rather than continuous, as previously assumed. However it is well known that the output rate of cells from the ...
An overview of the impact of described thymic defects on the Treg compartment will be provided, illustrating the importance of these in vivo models to investigate human Treg development. 展开 关键词: human thymus regulatory T-cells FOXP3 regulatory T-cell development human thymic defects primary ...
Thymus physiology and T-cell development can be controlled by hormones, via a variety of endocrine and paracrine pathways Microenvironmental cells in the thymus constitutively produce hormones that are typically secreted by the pituitary gland, such as growth hormone, prolactin, oxytocin and vasopressin ...
T-Cell DevelopmentThis volume provides simple and accessible experiment protocols to explore thymus biology. T-Cell Development: Methods and Protocols is divided into...doi:10.1007/978-1-4939-2809-5Rémy BosselutMelanie S. VacchioSpringer New YorkMethods in Molecular Biology...
Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus 从多能干细胞产生胸腺组织将为获得性和先天性胸腺功能不全状态提供治疗。 Gras-Peña等已经使用新方案从多能干细胞产生了人类胸...
Aims: The purpose of this study was to determine whether B cells drive T cell development and TCR diversification in the thymus. Methods: We compared the number of sub-populations of thymocytes and TCR repertoire diversity in B-cell deficient and B-cell proficient mice and in B cell deficient...
The Late Stage of T Cell Development within Mouse Thymus Cellular & Molecular Immunology. 2004;1(1):3-11.中国免疫学杂志(英文版)WeifengChenChen W. The late stage of T cell development within mouse thymus. ... WeifengChen - 《中国免疫学杂志(英文版)》 被引量: 21发表: 2004年 The Late St...
Transcriptional regulation of early T-cell development in the thymus. Eur. J. Immunol. 46, 531–538 (2016). Article CAS PubMed Google Scholar Thompson, P. K. & Zúñiga-Pflücker, J. C. On becoming a T cell, a convergence of factors kick it up a Notch along the way. Semin. ...