Regulatory T (Treg) cells are a distinct subset of CD4+ T cells, crucial for the establishment and maintenance of immunological self-tolerance and homeostasis. The majority of them develop in the thymus via recognition of self-antigens presented in the context of self-MHC molecule. While strong...
The thymus generates a lineage-committed subset of regulatory T-cells (Tregs), best identified by the expression of the transcription factor FOXP3. The development of thymus-derived Tregs is known to require high-avidity interaction with MHC-self peptides leading to the generation of self-reactive...
Ma D, Wei Y, Liu F (2013) Regulatory mechanisms of thymus and T cell development. Dev Comp Immunol 39(1–2):91–102. : 10.1016/j.dci.2011.12.013Ma, D., Wei, Y., and Liu, F. (2011). Regulatory mechanisms of thymus and T cell development. Dev Comp Immunol....
Cytokine signaling is indispensable for regulatory T-cell (Treg) development in the thymus, and also influences the homeostasis, phenotypic diversity, and function of Tregs in the periphery. Because Tregs are required for establishment and maintenance of immunological self-tolerance, investigating the rol...
Human thymopoiesis and T cell development in the former and latter models occur in the recipient mouse thymus and human thymic grafts, respectively. In this chapter, we summarize information on human T cell development, post-thymic interactions between T cells and APCs, as well as mechanisms ...
Regulatory T cells play critical roles in the control and modulation of immune responses. Here the authors implicate heterochromatic gene silencing in the susceptibility of CD4+ T cell to regulatory T cell suppressive function in a murine allograft model of inflammation. Julie Noguerol Karl Laviolette...
Foxp3 regulatory T cells develop in the thymus and are essential for maintaining peripheral tolerance to self tissues. We report the critical requirement for CD154 up-regulation specifically on, and during the thymic development of, Foxp3 regulatory T cells for the induction of their clonal expansi...
DevelopmentThymusPeriphery (primarily gut)In vitro Progenitor cellCD4single-positive cells CD25+Foxp3–orCD25–Foxp3lowNaiveCD4+cellsNaiveCD4+cells Surface phenotypeCD4+CD25hiCD127lowCD62LhiCD44lowCD45RBlow(mice)CD4+CD25hiCD127lowor CD4+CD25hiCD45ROhi(human)CD4+CD...
DevelopmentThymusPeriphery (primarily gut)In vitro Progenitor cellCD4single-positive cells CD25+Foxp3–orCD25–Foxp3lowNaiveCD4+cellsNaiveCD4+cells Surface phenotypeCD4+CD25hiCD127lowCD62LhiCD44lowCD45RBlow(mice)CD4+CD25hiCD127lowor CD4+CD2...
Ma D, Wei Y, Liu F. Regulatory mechanisms of thymus and T cell development. Developmental and comparative immunology. 2013; 39(1-2):91-102. doi: 10.1016/j.dci.2011.12.013 PMID: 22227346.Ma D, Wei Y, Liu F. Regulatory mechanisms of thymus and T cell development. Dev Comp Immunol (...