Thymus development and function 来自 Semantic Scholar 喜欢 0 阅读量: 27 作者: T Boehm 摘要: Thymopoiesis is a complex and highly dynamic process. It involves reciprocal tissue interactions between epithelial cells derived from the endoderm of the anterior foregut and neural crest-derived mesenchyme ...
In mTECs, transcriptomic data suggest that TEs interact with transcription factors essential for mTEC development and function (e.g., PAX1 and REL), and immunopeptidomic data showed that TEs generate MHC-I-associated peptides implicated in thymocyte education. Notably, AIRE, FEZF2, an...
The origin and function of this cell remain unclear. We describe ... Charles R Kramer and , Hugh Potter - 《Revue Canadienne De Zoologie》 被引量: 36发表: 2002年 Synthesis and phosphorylation of ecdysteroids during ovarian development in the silkworm, Bombyx mori. In the silkworm, Bombyx ...
Since the thymus is so important for immune system development during childhood, a thymectomy during childhood (before puberty) can also lead to issues. When this happens, people may have lower T cell numbers in the long run. These are white blood cells that fight germs and disease. Children ...
Non-epithelial stromal cells in thymus development and function. Front Immunol. 2021:12. 9. Kato S. Thymic microvascular system. Microsc Res Tech. 1997;38(3):287–99. 10. Takahama Y. Journey through the thymus: stromal guides for T-cell devel- opment and selection. Nat Rev Immunol. 2006...
grafts or to makeantibodiesto certain antigens. Moreover, certain parts of the white pulp of thespleenandlymphnodes are much reduced in size. These results demonstrate that the T cells produced in the thymus and transported to the lymphoid tissues are crucial elements in the development of ...
The thymus gland controls the development of proper functioning T cells through selection processes based on the behavior of the T cells as they interact with other cells in the gland. These other cells serve to "test" the T cells for their appropriate responses. Positive selection (or survival...
Thymus-derived T regulatory (tTregs) cells play a crucial role in the maintenance of tolerance and immune homeostasis. Mechanisms and factors regulating tTreg development and function are widely investigated, but to a large degree still remain unclear. Our previous findings demonstrated that, in ...
The thymus is a primary immune organ and is essential for normal development and function of the immune system. The thymus continues to increase in size through the fetal period and after birth until puberty, at which time it reaches its greatest size and weight. Thymic weights (absolute and ...
Function Development Clinical points Thymomas Myasthaenia gravis Di George syndrome (22q deletion) Sources + Show all Anatomy Location Thymus 1/3 Synonyms: Bries The thymus gland is a soft bilobed organ which is encapsulated. It lies in the superior mediastinum and in the anterior ...