The generation of regulatory T (T(Reg)) cells in the thymus is crucial for immune homeostasis and self-tolerance. Recent discoveries have revealed the cellular and molecular mechanisms that govern the differentiation of a subset of developing thymocytes into natural T(Reg) cells. Several models, ...
In humans, the thymus begins to function very early in ontogeny and releases large numbers of T cells before the time of birth. However, the vast majority of developing thymocytes (>95%) die within the thymus as a result of stringent selection processes. Positive selection imposes self-MHC-...
2. An Invariant T Cell Receptor α Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib–restricted α/β T Cell Subpopulation in Mammals 3. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1...
[17] Stritesky G L, Jameson S C, Hogquist K A. Selection of self-reactive T cells in the thymus[J/OL]. Annu Rev Immunol, 2012, 30: 95-114 [2021-12-22]. https://pubmed.ncbi.nlm.nih.gov/22149933. DOI: 10.1146/annurev...
In addition, it is possible to deplete thymus lobes of their lymphoid cells and recolonize them with T-cell precursors of a different MHC haplotype to produce chimeric lobes. Recolonization can also be achieved with defined numbers or types of precursor cells, including a single micro-manipulated ...
The maturation of T cells in the thymus is dependent on the expression of major histocompatibility complex (MHC) molecules. By disruption of the MHC class II A$^b_eta$ gene in embryonic stem cells, mice were generated that lack cell surface expression of class II molecules. These MHC class...
This study uses single-cell RNA-seq to characterize different subsets of mouse thymic NKT cells. CAS PubMed PubMed Central Google Scholar Wang, H. & Hogquist, K. A. CCR7 defines a precursor for murine iNKT cells in thymus and periphery. eLife 7, e34793 (2018). PubMed PubMed Central...
In the thymus, the cells differentiate into different types of T cells such as helper cells, natural killer cells, regulatory cells, and cytotoxic cells. These cells in turn travel through the bloodstream to look for signs of unwanted invaders, at which point the cells swing into action to ...
T cells are generated in the thymus and exported to peripheral lymphoid organs, a process that is under hormonal control. In this article, the authors discuss the mechanisms of thymus-specific T-cell development and how hormone therapy can counteract the
The thymus generates a lineage-committed subset of regulatory T-cells (Tregs), best identified by the expression of the transcription factor FOXP3. The development of thymus-derived Tregs is known to require high-avidity interaction with MHC-self peptides leading to the generation of self-reactive...