Cell Mol Immunol. 2004; 1 :3–11.Chen W: The late stage of T cell development within mouse thymus. Cell Mol Immunol 2004, 1: 3–11.Chen W. The late stage of T cell development within mouse thymus. Cell Mol Immunol. 2004;1(1):3-11.Chen, W., The late stage of T cell ...
During the past year, there have been rapid advances in our understanding of the early events of T-cell development, at the molecular level. Studies at the transcriptional level of T-cell receptor gene regulation have started to yield important clues about how different T-cell-specific genes can...
The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development. Adv. Immunol. 83, 55–89 (2004). CAS PubMed Google Scholar Taniuchi, I., Sunshine, M.J., Festenstein, R. & Littman, D.R. Evidence for distinct CD4 silencer functions at different stages of...
SEPARATION OF STAGES IN THE DEVELOPMENT OF THE "T" CELLS INVOLVED IN CELL-MEDIATED IMMUNITY 喜欢 0 阅读量: 33 作者: Shortman,K.摘要: Density distribution analysis in continuous gradients of albumin has been used to study the development of cytotoxic lymphocytes (CL), to separate and ...
T-cell development provides an excellent model system for studying lineage commitment from a multipotent progenitor. The intrathymic development process has been thoroughly studied. The molecular circuitry controlling it has been dissected and the necess
Extra-thymic development of T cells has been described for Oncostatin M (OncM) transgenic mice, where LNs take over the function of the thymus [24]. Even though in OncM mice the T cells appear to go through the same developmental stages as regular thymocytes, they are less functional, ...
While CD8β expression clearly identifies thymocytes that are virtually 100% positive for intracellular TCR-β,26 certain earlier stages of human T-cell development also contain TCR-β+ thymocytes.18,19 This prompted us to further characterize this stage, using markers that were recently proposed.18...
[3] Yang Q, Jeremiah Bell J, Bhandoola A. T-cell lineagedetermination[J]. Immunol Rev, 2010, 238(1): 12-22. [4] Hosokawa H, Rothenberg E V. Cytokines, transcription factors, and the initiation of T-cell development[J/OL]...
Figure 1. Cytotoxic T cell (CD8+T cell) engaging with target cell for destruction. Development of CD8+T cells The development of CD8+T-αβ cells begins with lymphoid progenitors in the thymus, which proceed through a double-negative (DN) (CD8–CD4–) phase,...
Phenotypic and functional stages in the intrathymic development of αβ T cells - ScienceDirect 来自 Semantic Scholar 喜欢 0 阅读量: 43 作者:Janko,Nikoli-ugi 摘要: The thymus is the main site o f T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell ...