B-cell development.Stages of B-cell maturation are indicated by their anatomical site and the expr...
Reference to a study by K. L. Medina et al, which appeared in a 2004 issue of "Dev. Cell"; Transcription factors for B cells; Developmental stages in becoming a B cell.doi:10.1038/nri1506Kirsty Mintonnature reviews immunology
c. CD62L expression of different B cell development stages in wildtype (WT) and NCOR1/2-knockout (DKO) B cells. Top represents representative flow cytometry plots for CD62L expression and bottom represents summarized frequency of CD62L + cells for prepro B (B220 + CD43 +...
The status of Ig loci rearrangements in single cells from different stages of B cell development. Differential expression of c-kit, CD25 (TAC), surrogate L chain and cytoplasmic muH chain, and surface expression of IgM and IgD allows the separation of B... ten,Boekel,Melchers,... - 《Inte...
B-cell development 邻家的妹妹,天真少女(IgM,IgD) 男人熏陶,则成---? 阿姨或鸡。(IgA,,IgE, IgG) 故初恋不可不慎也。 且看: B-cell maturation consists of early(antigen-independent) and late (antigen-dependent) stages.邻家的妹妹,天真少女(IgM,IgD) Early...
Hartley SB, Cooke MP, Fulcher DA, Harris AW, Cory S, Basten A et al (1993) Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72(3):325–335. https://doi.org/10.1016/0092-8674(93)90111-3 ...
B cell-specific deletion of Dicer exhibited a developmental block at the pro-B to pre-B stages and revealed that miRNAs may have a role in controlling V(D)J recombination for generating antibody diversity in the early stage of B cell development [40]. We have investigated the changes in ...
cells contain cytoplasmic immunoglobulins whereas mature B cells expresssurface immunoglobulinandcomplement receptors. B cell markers include CD9,CD19,CD20, CD24,Fc receptors, B1, BA-1, B4 and Ia.Figure 8.1shows theontogenyof B cells and thesurfacemarkers expressed on B cells at different stages....
B lymphocytes are a population of white blood cells that express clonally diverse cell surface Ig (immunoglobulin) receptors, recognizing specific antigenic epitopes. The development of B-cells encompasses a continuum of stages that begin in primary ...
Summary: One remarkable feature of the immune system is its capacity to maintain constant numbers of resting immune cells despite the complex nature of signals needed throughout development and maturation. For many years, B-cell survival was thought to rely solely on B-cell receptor (BCR) tonic...