Targeting of immune cells by bispecific antibodies has proven a powerful tool for the investigation of cellular cytotoxicity, lymphocyte activation and induction of cytokine production, as well as to represent an innovative form of immunotherapy for the treatment of cancer. The hallmark of this approach...
MHC-I expression was significantly upregulated (one-way ANOVA,P < 0.01) by cell intrinsic mechanisms on the tumor cells, potentially enhancing their ability to present antigen to CD8+OT-I ovalbumin-specific T cells (Fig.3a). We next investigated the effector function of these CD8+OT-I ...
A critical step in CAR-T cell production is T-cell activation, which impacts the CAR-T transduction efficiency11,12, rate of CAR-T cell expansion13,14, and differentiation15,16. Synthetic artificial antigen presenting cells (aAPC) are often used to standardize the delivery of signal 1, T-ce...
Here, we discuss the function of γδ T cells in tumor immunology and their application to cancer therapy. Cancer: T cell subset could boost immunotherapy An under-researched subset of T cells may find application in cancer immunotherapy once their multiple roles are fully understood. Jang ...
[11] Wing J B, Tanaka A, Sakaguchi S. Human FOXP3(+) regulatory T cell heterogeneity and function in autoimmunity and cancer[J]. Immunity, 2019, 50 (2): 302-316. [12] Muth S, Klaric A, Radsak M, et a...
HLA-Haploidentical Transplantation with Regulatory and Conventional T-Cells Adoptive Immunotherapy in Pediatric Patients with High-Risk Acute Leukemia MS Massei,I Capolsini,K Perruccio,... - 《Transplantation & Cellular Therapy》 被引量: 0发表: 2021年 Regulatory T cells in transplantation tolerance. ...
Although it is expressed by all leukocytes, including T-, B-lymphocytes and dendritic cells, the immunoglobulin-like receptor CD31 is generally regarded by immunologists as a marker of endothelial cell lineage that lacks an established functional role in adaptive immunity. This perception has recently...
4.Plummer M, Schiffman M, Castle PE, Maucort-Boulch D, Wheeler CM, Group A. A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of unde...
Immunotherapy-induced CD8+ T cells instigate im- mune suppression in the tumor[J]. Mol Ther, 2014, 22(1): 206-218. SPRANGER S, SPAAPEN R M, ZHA Y, et al. Up- regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8+ T cells[J]. Sci ...
结果显示(4a)ICI-MC患者心脏和骨骼肌的Shannon diversity和ICI-相关结肠炎或克罗恩病中受累结肠相比更低。This result indicates the high clonality of TCR repertoires seen in ICI-MC compared with another immunotherapy-related toxicity associated with high infiltration of T cells....