这意味着由中国自主研发的,世界上… cancer 百科 CAR-T(一) CAR-T(Chimeric Antigen Receptor T-CellImmunotherapy)是指嵌合抗原受体T细胞免疫疗法。这是一种近几年刚被改良使用到临床上的新型细胞疗法,被认为是最有前景的肿瘤治疗方法之一[1]。与其… Hepburn...
That's the idea behind cancer immunotherapy. Dr. Steven Rosenberg's group at the National Cancer Institute uses RetroNectin reagent to introduce T-cell receptor genes recognizing specific cancer antigens into a patient's own lymphocytes. These engineered cells are then returned to the patient, wher...
Interviewer: So I will ask you a question one by one. OK. So the first one: CAR-T cell therapy is also a kind of immunotherapy. First of all, please introduce the main principle of this treatment method, and what are its ...
F. et al. Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment. Curr. Opin. Immunol. 25, 268–276 (2013). Article CAS PubMed Google Scholar Gajewski, T. F. The next hurdle in cancer immunotherapy: overcoming the non-T-cell-inflamed tumor ...
T-cell-based immunotherapy, such as CAR-T cells and bispecific T-cell engagers (BiTEs), has shown promising clinical outcomes in many cancers; however, these therapies have significant limitations, such as poor pharmacokinetics and the ability to target only one antigen on the cancer cells. In ...
12.Meng Y, Sun J, Wang X, Ma Y, Kong C, Zhang G, et al. The biological macromolecule Nocardia rubra cell-wall skeleton as an avenue for cell-based immunotherapy. J Cell Physiol (2019). doi: 10.1002/jcp.2...
Adoptive T-cell Immunotherapy 过继性T细胞免疫治疗综述(1) Abstract 摘要 Epstein-Barr virus (EBV) is associated with a range of malignancies involving B-cells, T-cells,natural killer (NK)-cells, epithelial cells and smooth muscle. All of these are associated with thelatent life cycles of EBV, ...
2024 年 3 月 14 日,浙江大学医学院附属第二医院的王良静/陈淑洁研究团队中Cell杂志发表了题为Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer的文章,他们的研究发现,约氏乳杆菌(L.johnsonii)与祖细胞耗竭的 CD8+T 细胞(Tpex,由 TCF7 编码的 TCF-1 高表达为...
Immunotherapies, specifically immune checkpoint inhibitors (ICIs) such as programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1(PD-L1), provided a significant advance in cancer treatment [1]. CAR-T cell therapy is a novel form of immunotherapy that employs genetic engineer...