Interviewer: So I will ask you a question one by one. OK. So the first one: CAR-T cell therapy is also a kind of immunotherapy. First of all, please introduce the main principle of this treatment method, and what are its ...
The two most common approaches revolve around genetically engineering T cells to introduce either a new T-cell receptor (TCR) or a chimeric antigen receptor (CAR) (Humphries 2013). Adoptive T-cell therapy involves removing a patient's T cells, modifying them ex vivo, and then reinfusing the...
F. et al. Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment. Curr. Opin. Immunol. 25, 268–276 (2013). Article CAS PubMed Google Scholar Gajewski, T. F. The next hurdle in cancer immunotherapy: overcoming the non-T-cell-inflamed tumor ...
[Key words]Engineered T cell receptor-T cell; Immunotherapy; Solid tumors; Tumor antigens; Chimeric antigens receptor-T cell 过继性T细胞治疗(adoptive T cell therapy,ACT)策略已成为癌症治疗的主要方式。T细胞受体工程T细胞(engineered T cell receptor-T ce...
CAR-T疗法( Chimeric Antigen Receptor T-Cell Immunotherapy ) , 指的是嵌合抗原受体T细胞免疫疗法。简单来说,就是通过对患者的T细胞(人体的- -种免疫细胞)进行基因改造,使其可以杀死体内的癌细胞。天然的T细胞是“普通兵种" ,而CAR-T相当于“特种兵”。 来自iPhone客户端6楼2019-05-24 13:14 回复 ...
T-cell-based immunotherapy, such as CAR-T cells and bispecific T-cell engagers (BiTEs), has shown promising clinical outcomes in many cancers; however, these therapies have significant limitations, such as poor pharmacokinetics and the ability to target only one antigen on the cancer cells. In ...
cancer immunotherapyCD8Cancer immunotherapies depend on effective CD8+Tcells for tumor elimination and long-term control, but these cells often undergo metabolic changes within the tumor microenvironment that hinder their function. Targeting these metabolic adaptations presents a promising strategy to enhance...
赛默飞的CTS; OpTmizer; T 细胞扩增 SFM 培养基,瓶装,是专为人类T淋巴细胞的生长和扩增而开发的。OpTmizer CTS T-Cell Expansion Medium是一种完整的无血清,无异种1X培养基,包含OpTmizer T-Ce。欢迎咨询和购买。
12.Meng Y, Sun J, Wang X, Ma Y, Kong C, Zhang G, et al. The biological macromolecule Nocardia rubra cell-wall skeleton as an avenue for cell-based immunotherapy. J Cell Physiol (2019). doi: 10.1002/jcp.2...