First comprehensive summary of the recent advances in the use of nanomaterials for enhancing NK cell-based tumor immunotherapy. • The mechanisms of NK cell activation and inhibition for immunotherapy. • Rational design and fabrication of nanomaterials to elaborately enhance NK cell-based tumor immu...
Natural killer (NK) cell-based immunotherapy has been considered a promising cell-based cancer treatment strategy with low side effects for early tumors and metastasis. However, the therapeutic efficacy is generally low in est...
2023年9月,河南郑州大学研发团队在《Biomedicine & Pharmacotherapy》期刊上发表了一篇论文:Driving natural killer cell-based cancer immunotherapy for cancer treatment: An arduous journey to promising ground,该研究综述了几种方法来增强NK细胞的抗肿瘤活性,且已经进入临床阶段。 图源:参考资料2(下同) 方法一:NK细...
2025 年 2 月 10 日,中国科学技术大学生命科学与医学部、免疫应答与免疫治疗全国重点实验室王毅课题组在 Cell 子刊 Molecular Therapy 在线发表了题为“ A BPTF-specific PROTAC degrader enhances NK cell-based cancer immunotherapy ” 的研究论文 肿瘤
此外,【T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion】证明了利用原代人NK细胞进行TCR基因治疗是可能的。研究发现,原代NK细胞可以成功地用TCRα/β链进行基因修饰,同时添加CD8α/β共受体和包括所有四条CD3链的完整CD3复合体。提出了一种两步逆转录病毒...
Provided is a tumor immunotherapy method based on the activation of an NK cell. Further provided is a use of nucleobindin (NUCB) or a promoter thereof in the preparation of a drug or a preparation for promoting the proliferation of NK cells, treating tumors, and/or killing or inhibiting ...
近几年,自然杀伤细胞(Natural killer cell,NK)成为抗肿瘤免疫的焦点,也成为国自然的热点。本期,我们通过2022年7月份发表在Pharmacology & Therapeutics上的一篇综述,解读NK细胞的基本信息。 1.肿瘤微环境概述 肿瘤微环境(The tumor microenvironment,TME)是一个复杂的生态...
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity against tumors, different approaches have been developed for exploiting/harnessing their function in patients with leukemia...
3. A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization. (2018) Cell. Miguel F. Sanmamed and Lieping Chen. 4. The basic principles of chimeric antigen receptor (CAR) design. (2013) Cancer discovery. Michel Sadelain, Renier Brentjens, and Isabelle Riviere ...
where depletion of NK cell populations prior to tumor transplantation induces a more aggressive phenotype with metastatic tumors. These data have now formed a steppingstone to evaluate NK cell-based therapies in brain tumors, which are rapidly gaining attention as an attractive adoptive immunotherapy ...