First comprehensive summary of the recent advances in the use of nanomaterials for enhancing NK cell-based tumor immunotherapy. • The mechanisms of NK cell activation and inhibition for immunotherapy. • Rational design and fabrication of nanomaterials to elaborately enhance NK cell-based tumor immu...
Natural killer (NK) cell-based immunotherapy has been considered a promising cell-based cancer treatment strategy with low side effects for early tumors and metastasis. However, the therapeutic efficacy is generally low in est...
Natural killer (NK) cells have crucial roles in tumor surveillance. We found that tumor-infiltrating NK cells in human liver cancers had small, fragmented mitochondria in their cytoplasm, whereas liver NK cells outside tumors, as well as peripheral NK cells, had normal large, tubular mitochondria...
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity against tumors, different approaches have been developed for exploiting/harnessing their function in patients with leukemia...
2023年9月,河南郑州大学研发团队在《Biomedicine & Pharmacotherapy》期刊上发表了一篇论文:Driving natural killer cell-based cancer immunotherapy for cancer treatment: An arduous journey to promising ground,该研究综述了几种方法来增强NK细胞的抗肿瘤活性,且已经进入临床阶段。 图源:参考资料2(下同) 方法一:NK细...
1. Zhong Y, Liu J. Emerging roles of CAR-NK cell therapies in tumor immunotherapy: current status and future directions.Cell Death Discov2024; 10:318. 2. Cichocki F, van der Stegen SJC, Miller JS. Engineered and b...
此外,【T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion】证明了利用原代人NK细胞进行TCR基因治疗是可能的。研究发现,原代NK细胞可以成功地用TCRα/β链进行基因修饰,同时添加CD8α/β共受体和包括所有四条CD3链的完整CD3复合体。提出了一种两步逆转录病毒...
Figure 7. BH3 mimetics synergize with pre-activated NK cells in reducing tumor burden and prolonging mouse survival 最后在补充材料中,作者提出这种联用策略对于T细胞治疗来说也同样适用。 参考文献 Pan R, Ryan J, Pan D, et al. Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosi...
Zou, W. Mechanistic insights into cancer immunity and immunotherapy. Cell. Mol. Immunol. 15, 419–420 (2018). Article CAS PubMed PubMed Central Google Scholar Barry, K. C. et al. A natural killer–dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat. Med....
Provided is a tumor immunotherapy method based on the activation of an NK cell. Further provided is a use of nucleobindin (NUCB) or a promoter thereof in the preparation of a drug or a preparation for promoting the proliferation of NK cells, treating tumors, and/or killing or inhibiting ...