expansion, navigate complex physical barriers and modulate tumour microenvironments. Here, we present an overview of nanomaterials that have been used to overcome clinical barriers to T-cell-based immunotherapies and provide our outlook of this emerging field at the interface of cancer immunotherapy and...
(BREAT) cells in humantumor cell lines,xenograft tumors, andskin lesions, thereby killing tumors; these results support the potential of ALDH1A1-basedimmunotherapyto target CSCs.166Additionally, Di et al found naturally occurring multifunctional CD4+and CD8+T cells specific for the stem cell marker...
expansion, navigate complex physical barriers and modulate tumour microenvironments. Here, we present an overview of nanomaterials that have been used to overcome clinical barriers to T-cell-based immunotherapies and provide our outlook of this emerging field at the interface of cancer immunotherapy and...
The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory response. Analysing the TCR repertoire may help to gain a better understanding of the immune system featur...
Active Immunotherapy for Cancer Surgical Research Book2001, Surgical Research Keith D. Amos, ... Timothy J. Eberlein Explore book B. Proliferation Proliferation of T cells is easily measured after T cell activation. The simplest method is simple cell counting using trypan blue exclusion and a hem...
That's the idea behind cancer immunotherapy. Dr. Steven Rosenberg's group at the National Cancer Institute uses RetroNectin reagent to introduce T-cell receptor genes recognizing specific cancer antigens into a patient's own lymphocytes. These engineered cells are then returned to the patient, wher...
Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of care across a growing number of cancer indications. While the majority of cancer imm
The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory response. Analysing the TCR repertoire may help to gain a bette
CAR-T有一个复杂的全称:ChimericAntigenReceptorT-CellImmunotherapy。从它「原材料」T细胞可以看出,这款世人瞩目的肿瘤治疗手段,有一个大家更熟悉的名字「细胞免疫疗法」。2013年,Science杂志曾将肿瘤免疫治疗列为年度十大科学突破的首位,其中特别提到了CAR-T细胞。▶ 率先冲线的CTL019CAR-T疗法其实总计有300多项正在...
2024 年 3 月 14 日,浙江大学医学院附属第二医院的王良静/陈淑洁研究团队中Cell杂志发表了题为Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer的文章,他们的研究发现,约氏乳杆菌(L.johnsonii)与祖细胞耗竭的 CD8+T 细胞(Tpex,由 TCF7 编码的 TCF-1 高表达为...