Active movement of T cells away from a chemokine. Nat. Med. 6, 543 - 548.Poznansky M C,Olszak I T,Foxall R,et al.Active movement of T cells away from a chemokine. Nature Medicine . 2000Poznansky M C,Olszak I T,Foxall R,et al.Active movement of T cells away from a chemokine....
SSA 可通过诱导趋化因子 C-C 基序配体 25(C-C motif chemokine ligand 25,CCL25)和 Notch 配体(Notch ligand delta-like ligand 4, DLL4)的表达, 促进 TSP 进入胸腺;同时,通过诱导 Notch 配体 DLL4 的表达,促进胸腺细胞分化,增加初始 T 细胞的输出[67...
PARP inhibitor radiosensitization enhances anti-PD-L1 immunotherapy through stabilizing chemokine mRNA in small cell lung cancer ‘Small cell lung cancers do not respond well to immune checkpoint blockade therapy, due to the poor recruitment of CD8 + T cells to the tumours. Here authors show ...
PARP inhibitor radiosensitization enhances anti-PD-L1 immunotherapy through stabilizing chemokine mRNA in small cell lung cancer ‘Small cell lung cancers do not respond well to immune checkpoint blockade therapy, due to the poor recruitment of CD8 + T cells to the tumours. Here authors show...
chemokine network released from sepsis-trained resident macrophages that triggers tissue residency of T cells via CCR2 andCXCR6stimulations as the immune mechanism responsible for this decreased risk of de novo tumor development after sepsis cure. While nonseptic inflammation does not provoke this ...
TGF-β can also directly affect CAR-T cells by suppressing the expression of chemokine receptors like C-X-C chemokine receptor type 3 (CXCR3), limiting their ability to infiltrate solid tumors [30]. Additionally, abnormal vascular structures within solid tumors often reduce levels of adhesion ...
Figure 1. Role of T cells in adaptive immune response. Here we present an example of the content from the T Cell Stimulation and Proliferation eLearning course. Role of T Cells T cells are primarily ...
During lymphopoiesis, T-αβ cells develop from CD34+ hematopoietic stem cells which acquire CD2, CD5, and CD7 markers before exiting the bone marrow. In the thymus, these cells express CD3, after which they acquire both CD4+ and CD8+ (DP state). They then ...
Sustained superiority of CAR’TCR-T cells after repetitive stimulation To explore whether simultaneous stimulation through CAR and TCR results in faster exhaustion of CAR’TCR-T cells, we performed long-term repetitive co-culture experiments. Confirming our earlier finding from short-term stimulation, ...
Naked mole-rats (NMRs) are best known for their extreme longevity and cancer resistance, suggesting that their immune system might have evolved to facilitate these phenotypes. Natural killer (NK) and T cells have evolved to detect and destroy cells infec