Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells. Eur J Immunol 1999;29:1925-32.Kanazawa N,Nakamura T,Tashiro K,et al.Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic ...
It is now important to validate the pathogenic role of CCL18 and other potential T cell-attracting chemokines in other limb and VCA transplantation cohorts. Limb transplantation is a clinically feasible procedure for amputees, and use of a solid organ transplantation-based immunosuppressive regimen has...
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization Article 18 November 2021 Accession codes Accessions Gene Expression Omnibus GSE6743 References Kunkel, E.J. & Butcher, E.C. Chemokines and the tissue-specific migration of...
Alternatively, tumors such as ovarian can use epigenetic mechanisms to silence the T-cell attracting chemokines CXCL9 and CXCL10 [97]. In addition, nitrosylation by reactive oxygen species (ROS) in the TME abrogates the ability of CCL2 to attract T cells [98], while altered proteolytic ...
To explore how LSD1 affects the level of tumor-infiltrating CD8+ T cells, expressions of LSD1, CD8, and T-cell attracting chemokines, C-X-C motif chemokine 9 (CXCL9) and C-X-C motif chemokine 10 (CXCL10) were analyzed using IHC on tissue microarray (TMA) blockers constructed with ...
Active migration of T cells into the tumor is enforced through RT-dependent acti- vation of a type I interferon response, which induces the Local Interventions and CAR T Cells in Solid Tumors 627 secretion of several T cell-attracting chemokines [227, 228] such as CXCL9-11, CCL5, and ...
(EMT), inhibiting T-cell infiltration. Similarly, theFAM83Hgene can serve a similar role. Tumor cells may inhibit CD8 + T-cell recruitment by reducingFAT2gene expression, as well as negatively regulating chemokines such as CCL2, CCL3, CCL4, CCL19, CXCL10, and CXCL11 through various ...
fewer eosinophil-attracting chemokines and reduced eosinophil recruitment into the lung, which was beneficial to the host in reducing allergen-induced inflammation. Thus, we define a fundamental role for ST2+Tregcells in the lung as a negative regulator of the early innate γδ T cell response to...
Determining Whether Optimal Ex Vivo Th Cell Expansion Requires Production of Chemokines or Cytokines by the Dendritic Cell The results provided herein show that DC pulsed with the dually modified peptide, FR74.4, produce significantly higher levels of the T cell attracting chemokines, CCL7 (MCP-3)...
metastatic cancer cells, following stimulation with interferon-gamma. It acts via its GPC receptor on T-cells attracting them to various target tissues. Glycosaminoglycans (GAGs) are regarded as co-receptors of chemokines, which enable the establishment of a chemotactic gradient for target cell ...