T cell recruitmentT cell area dendritic cellDendritic cells (DC) are a system of antigen-presenting cells specialized in interaction with T cells. Recently it has been reported that DC can produce CC (尾) chemokines that attract T cells. In this study we isolated mouse fractalkine and ...
The presence of T cells in tumors predicts overall survival for cancer patients. However, why most tumors are poorly infiltrated by T cells is barely understood. T-cell recruitment towards the tumor requires a chemokine gradient of the critical IFNγ-induced chemokines CXCL9/10/11. Here, we de...
we examined the chemokines associated with T cell recruitment. RT-qPCR analysis was conducted on tumor-bearing mice after EPI injection, mirroring the results discussed above in result 4 (Fig.4e-h, k-l). The expression of chemokines (Ccl5, Cxcl9, Cxcl10, Cxcl11) and cytokines (IFN-γ, ...
The activation of T cells by Gag peptide stimulation in vitro was first evaluated by measuring the secretion of cytokines and chemokines into the culture supernatants. There was significantly enhanced secretion of IFN-γ in each sample (ranging from 10- to 100-fold) following stimulation with the ...
Co-expression of CCL5 and CXCL9 is key to CD8+ T cell recruitment, creating a loop to magnify lymphocyte engraftment [103]. However, it should be noted that the production of endogenous chemokines in CAR T cells may block chemokine receptors on their surface, resulting in attenuated migratory...
Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immuno
The early recruitment of non-conventional T-cells following a primary viral infection may enable the host to recognize viral-infected cells through NKp46 while retaining the possibility of establishing T-cell immune memory. 展开 关键词: bovine herpesvirus-1 chemokines interferon-γ lymphocyte ...
Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells Nature, 486 (2012), pp. 545-548 CrossrefView in ScopusGoogle Scholar Henrickson and von Andrian, 2007 S.E. Henrickson, U.H. von Andrian Single-cell dynamics of T-cell priming Curr. Opin. Immunol.,...
However, these chemokines are less expressed in tumor tissue. In summary, due to the lack of expression of chemokines involved in the penetration of T cells into tumor tissues, as well as the presence of dense fibrotic matrix in solid tumors, CAR’s ability to migrate and invade tumor cells...
(STING) pathway activation enhanced T cell recruitment and effector cell function in tumors [122]. Another scRNA-seq study combined the STING agonists DMXAA/cGAMP with CAR T-cells to treat mice with breast cancer. The results demonstrated that compared to CAR T-cell infusion alone, DMXAA/cGAMP...