Cancer Immunol Res 丨刘光伟/毕玉晶发现滤泡辅助性T细胞分化调控肿瘤免疫新机制 细胞免疫疗法已经显示出抗肿瘤免疫治疗的独特优势。在免疫细胞抗肿瘤治疗中,CD4+T细胞可以通过发育分化为滤泡辅助T细胞(follicular T helper cells; TFH)并通过...
CD4 + follicular helper T cell infiltration predicts breast cancer survival. J Clin Invest. 2013; 123 (7):2873–2892.Gu-Trantien C, Loi S, Garaud S, Equeter C, Libin M, et al. (2013) CD4(+) follicular helper T cell infiltration predicts breast cancer survival . J C...
在免疫细胞抗肿瘤治疗中,CD4+T细胞可以通过发育分化为滤泡辅助T细胞(follicular T helper cells; TFH)并通过调节生发中心(germinal center; GC),可以直接影响B细胞分化和成熟,介导抗肿瘤体液适应性免疫调节。然而,TFH细胞分化和调节的机制目前尚不完全清楚。 2024年4月18日,生命科学学院刘光伟教授团队、军事医学研究院毕...
Functional TH1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity. J. Clin. Invest. 131, e139905 (2021). Article CAS PubMed PubMed Central Google Scholar Sackstein, R., Schatton, T. & Barthel, S. R. T-lymphocyte homing: an ...
According to this immune prognostic risk score, immune signature of T follicular helper cells is an independent and specific prognostic signature for predictions of LUSC patient overall survival. Moreover, high-risk group exhibited less expression of N6-methyladenosine (m6A) RNA methylation regulator ...
T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer. ...
Rezende, R. M. et al. γδ T cells control humoral immune response by inducing T follicular helper cell differentiation.Nat. Commun., 3151 (2018). ArticlePubMed Bansal, R. R., Mackay, C. R., Moser, B. & Eberl, M. IL-21 enhances the potential of human γδ T cells to provide ...
滤泡辅助性T细胞(follicular helper T cell, Tfh细胞)和滤泡调节性T细胞(follicular regulatory T cell, Tfr细胞)是具有相反作用的CD4+T细胞亚群。伴随着生发中心反应,一类由胸腺来源的nTreg细胞分化形成Tfr能够负向调控体液免疫的中心轴“Tfh–B细胞–抗体”。Tfh细胞和Tfr细胞的免疫平衡对促进生发中心的正常形成、B...
I. Enumeration of gamma-interferon-secreting cells. J. Immunol. Methods 110, 29–36 (1988). Article CAS PubMed Google Scholar Dan, J. M. et al. A cytokine-independent approach to identify antigen-specific human germinal center T follicular helper cells and rare antigen-specific CD4+ T ...
摘要: Colorectal cancer is considered to be one of the major causes of morbidity and mortality all over the world. T Follicular helper (T-FH) and T follicular regulatory (T-FR) cells are... 查看全部>>关键词: T Follicular helper T follicular regulatory cells colorectal cancer ...