follicular helper t (tfh) cells are a specific subset of cd4+ helper t cells (th), normally found in the germinal centers of b-cell follicles. they provide help to b cells and cause them to differentiate into long-lived, antibody-secreting plasma cells or memory b cells. tfh cells have...
T follicular helper (Tfh) cells are a subset of CD4 positive t helper cells that are critical for mounting immune responses against pathogens.
Abbreviations:CD, cluster of differentiation; BATF, basic leucine zipper transcriptional factor ATF-like; BCL, B cell lymphoma; ICOS, inducible t cell costimulatory; IL, interleukin; IRF, interferon regulatory factor; PD, programmed cell death protein; STAT, signal transducer and activator of transcr...
Abbreviations:CD, cluster of differentiation; BATF, basic leucine zipper transcriptional factor ATF-like; BCL, B cell lymphoma; ICOS, inducible t cell costimulatory; IL, interleukin; IRF, interferon regulatory factor; PD, programmed cell death protein; STAT, ...
Follicular helper T cells (TFH) are able to closely interact with B cells to promote the formation of germinal centers (GCs). The stable cognate interaction between TFH and B cells in the GC is mutually beneficial to both cells for their development and function. Specifically, help B cells ...
T-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma Zhi-Zhang Yang, Hyo Jin Kim, Hongyan Wu, Xinyi Tang, Yue Yu, Jordan Krull, Daniel P. Larson, Raymond M. Moore, Matthew J. Maurer, ...
Follicular helper T‐cells: expanding roles in T‐cell lymphoma and targets for treatment 来自 科研支点 喜欢 0 阅读量: 57 作者:MJ Ahearne,RL Allchin,CP Fox,SD Wagner 摘要: SummaryFollicular helper T-cells (Tfh cells) are a subset of CD4+ T-cells that are essential for normal production ...
TFH cell development is regulated by a suite of transcriptional factors in conjunction with the master controller B cell lymphoma 6 (BCL-6). The classical cytokine-centric 'instructional' paradigm of T helper cell differentiation cannot fully explain how TFH cells develop and function. Key features...
neoplastic haematopathology, both in T-cell lymphomagenesis or as part of the tumour microenvironment in some B-cell neoplasms. III. FOLLICULAR HELPER T-CELLS During the last years, T follicular helper (T FH ) cells have emerged as a separate minor functional subset of effector T helper...
Abbreviations:CD, cluster of differentiation; BATF, basic leucine zipper transcriptional factor ATF-like; BCL, B cell lymphoma; ICOS, inducible t cell costimulatory; IL, interleukin; IRF, interferon regulatory factor; PD, programmed cell death protein; STAT, ...