Tfh cellsantibodyCXCR5Bcl6ICOSdiseaseFollicular helper T (Tfh) cells are a subset of helper T cells with specialised functions to support high-affinity and long-term antibody responses. Tfh cells express high levels of transcription factor Bcl6, chemokine receptor CXCR5, cytokine IL-21 and ...
滤泡辅助性T(Follicular helper T,TFH)细胞是CD4+ T细胞的一个特殊亚群,表达趋化因子受体CXCR5,主要支持生发中心(germinal center, GC)反应,在生发中心反应中产生高亲和力和长期的体液免疫,调节记忆性和抗体分泌性B细胞的克隆选择和分化,从而控制抗体记忆和亲和力成熟。 其在...
t cells follicular helper翻译 T细胞滤泡辅助器(Tfh)是一种负责为B细胞提供帮助的T细胞亚群。它们主要存在于淋巴结和其他淋巴组织中的淋巴滤泡内,从而形成一个高度分化的治愈中心(GC),与B细胞一起产生高亲和力的抗体。由于其对提高免疫应答和维持体内免疫记忆非常重要,因此Tfh细胞已成为外科医生和免疫学家的广泛研究...
Tfh细胞(Follicular helper T cell)是参与体液免疫的辅助性T细胞亚群,直接来源于初始T细胞,存在于扁桃体、淋巴结等淋巴组织中。Tfh细胞分泌细胞因子刺激B细胞增殖以及免疫球蛋白的转换,通过刺激生发中心(GC),B细胞分化成为浆细胞和记忆B细胞,参与体液免疫。并且Tfh细胞通过分泌IL-21增强CD8+T细胞功能,参与细胞免疫。 研...
4. Mahnke YD, Beddall MH, Roederer M. OMIP-017: human CD4(+) helper T-cell subsets including follicular helper cells. Cytometry A. 2013;83(5):439-440. 5. Geginat J, Paroni M, Maglie S, et al. Plasticity of human CD4 T cell subsets. Front Immunol. 2014;5:630. Published 2014 ...
滤泡辅助性T细胞(follicular helper T cells,Tfh)是一群新发现的独立的CD4+T细胞亚群,趋化因子受体5(C-X-C chemokine receptor type 5,CXCR5)、程序性细胞死亡蛋白-1(programmed cell death protein 1,PD-1)、诱导性共刺激分子(inducibl...
Tfh细胞(Follicular helper T cell)是参与体液免疫的辅助性T细胞亚群,直接来源于初始T细胞,存在于扁桃体、淋巴结等淋巴组织中。Tfh细胞分泌细胞因子刺激B细胞增殖以及免疫球蛋白的转换,通过刺激生发中心(GC),B细胞分化成为浆细胞和记忆B细胞,参与体液免疫。并且Tfh细胞通过分泌IL-21增强CD8+T细胞功能,参与细胞免疫。
Follicular helper T cells (TFH) are able to closely interact with B cells to promote the formation of germinal centers (GCs). The stable cognate interaction between TFH and B cells in the GC is mutually beneficial to both cells for their development and function. Specifically, help B cells ...
T follicular helper (Tfh) cells are a subset of CD4 positive t helper cells that are critical for mounting immune responses against pathogens.
T follicular helper (Tfh) cells are a subset of CD4 positive t helper cells that are critical for mounting immune responses against pathogens.