[5] Gaud G, Lesourne R, Love P E. Regulatory mechanisms in T cell receptor signalling [J]. Nature Reviews Immunology, 2018, 18(8): 485-497. 基迪奥生物|专业定制测序服务 联系方式:020-39341079;service@genedenovo.com
Journal of Cell ScienceLin J, Weiss A (2001) T cell receptor signalling. J Cell Sci 114:243-244.Lin, J., and A. Weiss. 2001. T cell receptor signalling. J Cell Sci 114:243-4.Lin J, Weiss A (2001). T cell receptor signalling. J Cell Sci 114, 243-244....
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development Article Open access 21 May 2020 Structural understanding of T cell receptor triggering Article 11 February 2020 IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses...
T细胞是适应性免疫反应的主要细胞类型,在病原体清除和肿瘤监测中发挥核心作用。T细胞受体(T cell receptor,TCR)可以让T细胞特异性识别靶细胞膜表面的抗原(由MHC复合物呈递)并激发细胞免疫反应。关于T细胞以及TCR如何体内如何发育成熟,在基迪奥系列丛书《单细胞测序完全解析》中的第五章有专门介绍,这里就不重复赘述。本期...
The limited availability of cytokines in solid tumours hinders maintenance of the antitumour activity of chimeric antigen receptor (CAR) T cells. Cytokine receptor signalling pathways in CAR T cells can be activated by tra...
We discuss how these findings highlight the importance of spatial segregation of individual signalling components as a way of regulating T cell responsiveness and immune tolerance. 展开 关键词: SRC-FAMILY KINASES LYMPHOID TYROSINE PHOSPHATASE IMMUNOLOGICAL SYNAPSE ANTIGEN RECEPTOR TRANSMEMBRANE ADAPTER ACTIN...
Human T-cell receptor triggering requires inactivation of Lim kinase-1 by Slingshot-1 phosphatase This study identifies a role for the phosphatase Slingshot-1 in controlling LIMK1 and PAK1 signalling to achieve the cytoskeletal rearrangements that facilitate NCK recruitment to the T-cell receptor and...
近日,四川大学生物治疗国家重点实验室胡洪波课题组联合刘兵团队和兰雨团队,在针对人类胚胎时期T细胞起源和发育的研究中又做出了重大发现,三个课题组共同合作的题为Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Ly...
Programmed death receptor 1 (PD-1) recognizes ligands such as PD-L1 on tumor cells to evade host immune responses. Inhibition of the programmed cell death ligand 1 (PD-L1) pathway has emerged as a promising strategy for the treatment of tumors [119]. PD-L1 expression ranged from 39 to ...
过继性免疫细胞治疗(Adoptive cell therapy, ACT) 自 1982 年首次被报道以来,迅速成为了肿瘤免疫治疗的主要方法之一。 从一开始的杀伤细胞(lymphokine activated killer cell)到今天通过改造 T 细胞而形成嵌合抗原受体的 T 细胞 (chimeric antigen receptor-engineered T cell, CART),ACT 的应用显著提高了晚期癌症患...