Quiescent 静止的 2. R RCT随机对照试验 recombinant 重组体 random-effects随机效应 retinoids维甲酸,类维生素A recombinant protein 重组蛋白 Robust 强大的 recipient 接受者 transepidermal water loss(TEWL)经表皮水分流失 rash 皮疹 rarity 稀有 receptor for advanced glycation end products (RAGE) 晚期糖基化终产...
The present disclosure relates to a recombinant T cell receptor capable of binding to a tyrosine kinase epitope, a maga-a1 epitope, a mar1 epitope, a MAGE-A3 epitope, or an SSX2 epitope and a nucleic acid molecule encoding them.In some embodiments, the nucleic acid molecule further ...
T cell receptor (TCR) signaling regulates important developmental transitions, partly through induction of the E protein antagonist, Id3. Although normal γδ T cell development depends on Id3, Id3 deficiency produces different phenotypes in distinct γδ T cell subsets. Here, we show that Id3 def...
The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory response. Analysing the TCR repertoire may help to gain a better understanding of the immune system featur...
Using T cell receptor analysis, we determined the clonal overlap between memory T cell subsets within the lung and within the LDLN, and this was greater than the clonal overlap observed between memory T cell subsets compared across tissues. Our results suggest that lung and LDLN memory T ...
Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma (NHL) of mature B-cells characterized by translocation, which is typically due to excess expression of Cyclin D1. Although with the progress in our knowledge of the causes for MCL and availa
Bar diagram: quantification of Fluo-4-AM signal on 200 individual cells, recorded for 10 min. Ca2+ flux on each cell was calculated by the difference between the maximal and minimal intensity of Fluo-4-AM fluorescence (peak value). (C and D) Ratiometric assays of Ca2+ flux by FACS in ...
Although priming by LSECs induces T cell nonresponsiveness toward isolated T cell receptor (TCR) signaling (Diehl et al., 2008; Limmer et al., 2000; Schurich et al., 2010), liver-primed T cells were not terminally committed to their nonresponsive state but rather acquired a differentiation...
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ARTICLE Received 16 Sep 2016 | Accepted 14 Mar 2017 | Published 16 May 2017 DOI: 10.1038/ncomms15260 OPEN An allosteric site in the T-cell receptor Cb domain plays a critical signalling role Kannan Natarajan1, Andrew C. McShan2, Jiansheng Jiang1, Vlad K. Kumirov2, Rui Wang1, Huaying ...