T-cell receptors (TCRs) recognize small protein fragments (peptides) that are displayed on the surface of antigen-presenting cells. Each T cell expresses a unique TCR that is generated by randomly assorting genes. This ensures that T cells can respond (at the population level) to almost any...
T-Cell Receptors CD4 and CD8 T cells express a unique surface receptor, the T-cell receptor (TCR) that determines the MHC restriction and peptide specificity of an individual T cell. In the vast majority of T cells, this is a heterodimeric receptor comprised of the TCR α- and β-chains...
T cells usually express CD4 or CD8 coreceptors, and therefore pMHC-bound TCR browses for LCK-loaded coreceptors where the non-polymorphic part of pMHCs interacts with the distal membrane part of the coreceptors.76,77,78,79 The membrane-distal D1 domain of CD4 associates with the membrane-...
必应词典为您提供T-Cell-Receptors的释义,网络释义: T细胞受体;
[30]. γδ T-cell receptors are not widely studied, as γδ T cells only account for a small proportion of the total T cell population. The overall diversity of γδ TCRs is lower, compared to αβ TCRs, and there is an abundance bias based on which anatomical location is being ...
Partial primary structure of the alpha and beta chains of human tumor T-cell receptors. Science 227: 311–314, 1985 Google Scholar Jores, R. and Meo, T. Few V gene segments dominate the T cell receptor β-chain repertoire of the human thymus. J Immunol 151: 6110–6122, 1993 Google ...
T cells specifically recognize pHLA with their clonally rearranged T-cell receptors (TCRs), whose natural affinities are limited to approximately 1-100 muM. Here we describe the display of ten different human TCRs on the surface of bacteriophage, stabilized by a nonnative interchain disulfide bond...
γδ T-cell receptors are not widely studied, as γδ T cells only account for a small proportion of the total T cell population. The overall diversity of γδ TCRs is lower, compared to αβ TCRs, and there is an abundance bias based on which anatomical location is being analysed, ...
Whether these receptors also influence g... K Terrence,CP Pavlovich,EO Matechak,... - 《Journal of Experimental Medicine》 被引量: 198发表: 2000年 Expression of T-Cell Receptor β-Chain mRNA and Proteinin γ/δ T-Cells from Euthymic and Athymic Rats:Implications for T-Cell Lineage ...
KRAS mutations are broadly recognized as promising targets for tumor therapy. T cell receptors (TCRs) can specifically recognize KRAS mutant neoantigens presented by human lymphocyte antigen (HLA) and mediate T cell responses to eliminate tumor cells. In