KEGG通路图只展示了TCR信号通路的主干部分,其结构上并不复杂。考虑T细胞的重要性、其发育过程的复杂性以及细胞亚型的多样性,该信号通路相关的调控则非常复杂而多样。由于细胞治疗、免疫治疗的兴起,TCR信号传导通路成为癌症治疗领域最受关注的通路,而PD1、CTLA4等该信号通路相关的调节基因都已经成为重要的靶向治疗靶点。尽...
T cell receptor signaling pathway 青云英语翻译 请在下面的文本框内输入文字,然后点击开始翻译按钮进行翻译,如果您看不到结果,请重新翻译! 翻译结果1翻译结果2翻译结果3翻译结果4翻译结果5 翻译结果1复制译文编辑译文朗读译文返回顶部 T细胞受体信号通路 翻译结果2复制译文编辑译文朗读译文返回顶部...
T Cell Receptor Signaling Pathway Background T cell receptors (TCR) play a key role in functioning of T cells and formation of the immunological synapse. It provides connection between T cell and the antigen-presenting cell (APC). TCRs activation promotes a number of signaling cascades that ult...
‹T-Cell Receptor (TCR) TCR Cell Signaling Pathway T-cells are a subset of lymphocytes that play a large role in the immune response. The TCR (T-cell receptor) is a complex of integral membrane proteins that participate in the activation of T-cells in ...
这是一篇粉丝来稿,该文献是2021发表在《Nature communication》的《Single cell T cell landscape and T cell receptor repertoire profifiling of AML in context of PD-1 blockade therapy》,文章介绍了在经过PD-1免疫治疗前后AML(急性髓细胞性白血病)病人T亚群和占比的变化,提出可以使用免疫治疗前T细胞克隆型和GZMK...
Objective:To develop and simulate a dynamic model dealing with the quantitatively regulatory relationship between interacting molecules involved in T cell receptor signaling pathway and analyze the dynamic traits of the model. Methods: Based on KEGG database and related literatures in English and Chinese...
T幼淋巴细胞白血病(T-cell prolymphocytic leukemia, T-PLL)是一种罕见的、临床病程异质性的成熟T细胞肿瘤。随着一些新治疗方案的出现,可能会改变T-PLL患者的临床管理,因此需要制定T-PLL的共识指南以更好地设计并实施临床试验。T幼淋巴细胞白血病国际工作组...
这是一篇粉丝来稿,该文献是2021发表在《Nature communication》的《Single cell T cell landscape and T cell receptor repertoire profifiling of AML in context of PD-1 blockade therapy》,文章介绍了在经过PD-1免疫治疗前后AML(急性髓细胞性白血病)病人T亚群和占比的变化,提出可以使用免疫治疗前T细胞克隆型和GZMK...
炎症信号通路促进 T 细胞活化,参与 GVHD 的发病机制。细胞因子信号转导抑制因子1(SOCS1)是多种炎性细胞因子的重要负调节因子。然而,它在 T 细胞活化和移植物抗宿主病中的调节作用尚未阐明。来自健康供体的粒细胞集落刺激因子(G-CSF)施用的低反应性 T 细胞的转录组和染色质结构的多组学分析显示 G-CSF 通过...
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity Regulatory T (Treg) cells are functionally heterogeneous, yet how each Treg cell subset exerts its suppressor function remains unresolved. Lin et al. identify IL-27 as a key Treg cel...