KEGG通路图只展示了TCR信号通路的主干部分,其结构上并不复杂。考虑T细胞的重要性、其发育过程的复杂性以及细胞亚型的多样性,该信号通路相关的调控则非常复杂而多样。由于细胞治疗、免疫治疗的兴起,TCR信号传导通路成为癌症治疗领域最受关注的通路,而PD1、CTLA4等该信号通路相关的调节基因都已经成为重要的靶向治疗靶点。尽...
T cell receptor signaling pathway 青云英语翻译 请在下面的文本框内输入文字,然后点击开始翻译按钮进行翻译,如果您看不到结果,请重新翻译! 翻译结果1翻译结果2翻译结果3翻译结果4翻译结果5 翻译结果1复制译文编辑译文朗读译文返回顶部 T细胞受体信号通路 翻译结果2复制译文编辑译文朗读译文返回顶部...
T Cell Receptor Signaling Pathway Background T cell receptors (TCR) play a key role in functioning of T cells and formation of the immunological synapse. It provides connection between T cell and the antigen-presenting cell (APC). TCRs activation promotes a number of signaling cascades that ult...
The elucidation of the mechanisms underlying T cell receptor signaling pathway is of considerable interest and might lead to new insights into the mechanism of HAM/TSP. 展开 关键词: HTLV-1 HAM/TSP CD4+T cell activation Gene expression
这是一篇粉丝来稿,该文献是2021发表在《Nature communication》的《Single cell T cell landscape and T cell receptor repertoire profifiling of AML in context of PD-1 blockade therapy》,文章介绍了在经过PD-1免疫治疗前后AML(急性髓细胞性白血病)病人T亚群和占比的变化,提出可以使用免疫治疗前T细胞克隆型和GZMK...
T幼淋巴细胞白血病(T-cell prolymphocytic leukemia, T-PLL)是一种罕见的、临床病程异质性的成熟T细胞肿瘤。随着一些新治疗方案的出现,可能会改变T-PLL患者的临床管理,因此需要制定T-PLL的共识指南以更好地设计并实施临床试验。T幼淋巴细胞白血病国际工作组...
这是一篇粉丝来稿,该文献是2021发表在《Nature communication》的《Single cell T cell landscape and T cell receptor repertoire profifiling of AML in context of PD-1 blockade therapy》,文章介绍了在经过PD-1免疫治疗前后AML(急性髓细胞性白血病)病人T亚群和占比的变化,提出可以使用免疫治疗前T细胞克隆型和GZMK...
炎症信号通路促进 T 细胞活化,参与 GVHD 的发病机制。细胞因子信号转导抑制因子1(SOCS1)是多种炎性细胞因子的重要负调节因子。然而,它在 T 细胞活化和移植物抗宿主病中的调节作用尚未阐明。来自健康供体的粒细胞集落刺激因子(G-CSF)施用的低反应性 T 细胞的转录组和染色质结构的多组学分析显示 G-CSF 通过...
Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment, but further optimization is still direly needed. Here the authors perform a CRIS...
cell transplant for leukemia, increasing Tregs frequencies can reduce GVHD rates [23]. IFNγ receptor signaling significantly inhibits Treg expression and transformation of conventional T cells into Tregs. CRISPR–Cas9 technology can effectively delete the IFNγ receptor in CD4+T cells, substantially ...