THE NATURE OF RECEPTORS FOR ANTIGENS ON T-CELLSELSEVIERIr Genes and Ia Antigens
NK cells were washed, resuspended in IMDM supplemented with 10% FBS, and added to wells at the indicated effector-to-target (E/T) cell ratios. The supernatants were measured for 51Cr release on a γ-counter (Cobra II Auto-Gamma, Global Medical Instruments, Ramsey, MN). Flow cytometric ...
In summary, while there may well be more than one cell type or immune mechanism that mediates suppression, the in vitro and in vivo studies presented here establish that TCR a{3 com- plexes are expressed on one subset of human, antigen-responsive suppressor T cells. We are grateful to Dr...
Although inhibition of T cell coinhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. In the present study, we show that type 1 interferon (IFN-I) regulates coinhibito
F2-isoprostane receptors on hepatic stellate cells. F2-isoprostanes are considered as the most reliable markers of oxidative stress and can be used to evaluate the oxidative status in a number of human patho... Concetta,Gardi,Beatrice,... - Laboratory investigation; a journal of technical methods...
Interleukin-10 is up-regulated by prolactin and serum-starvation in cultured mammary epithelial cells We speculate that release of IL-10 from the epithelial cells recruits lymphocytes, which have IL-10 receptors on their cell membranes, and they in turn... K Tae-Won,M Hyung-Bae,KS Jung 被引...
OBJECTIVE: Our objective was to determine if angiotensin \{II\} receptors are present on adrenal cells isolated from the human fetal zone and neocortex and to investigate if angiotensin \{II\} affects steroid production by these cells. \{STUDY\} DESIGN: Primary cultures of both fetal zone and...
BACKGROUNDNodal, a TGFβ like growth factor, functions as an embryonic morphogen that maintains the pluripotency of embryonic stem cells. Nodal has been implicated in cancer progression; however, there is no information on expression and functions of Nodal in prostate cancer. In this study, we ha...
The cells exhibit unusual high Cl− contents (around 46 mM), whereas the mucus has relatively low concentrations (around 55 mM). This, together with the prevalent membrane potential (negative on the inside relative to the outside), leads to an outward flow of chloride ions when ANO2 ...
In activated T cells, co-inhibitory receptors control and contract the expanded T-cell population. In regulatory T cells (Tregs), co-inhibitory receptors, such as CTLA-4 and PD-1, promote the suppressive function of Tregs.8,9 In the scope of this review, we are going to focus on the ...