因此,重新激活 CD8+ TILs 亚群对增强肿瘤免疫治疗效果具有重要意义。 2021 年 5 月 25 日,瑞士洛桑联邦理工学院(EPFL)唐力教授团队在Nature Immunology上在线发表了题为 Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity 的研究成果。该研究发现,IL-10 通过上调...
During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage in glycolysis or amino acid metabolism but have an increased rate of fatty a
179. Hatori, M. et al. Time-restricted feeding without reducing caloric intakrevents metabolic diseases in mice fed a high-fat diet. Cell Metab. 15, 848–860 (2012). This study reports the efects on the healthspan of time-restricted feeding without calorie restriction. 180. Newman, J. C....
10–Fc was a safe and highly efficient metabolic intervention that synergized with adoptive T cell transfer immunotherapy, leading to eradication of established solid tumors and durable cures in the majority of treated mice. These findings show that metabolic reprogramming by upregulating mitochondrial ...
Metabolic reprogramming confers cancer cells plasticity and viability under harsh conditions. Such active alterations lead to cell metabolic dependency, which can be exploited as an attractive target in development of effective antitumor... T Yu,T Dong,H Eyvani,... - 《Archives of Biochemistry & ...
4. T cell activation requires the orchestration of signaling pathways and metabolic reprogramming 5. Memory T cells—remembering metabolic pathways 6. Regulatory T cells—against the (glycolytic) flow 7. Metabolism underlying T cell differentiation—key metabolic checkpoints and pathways 8. Future perspe...
6.STTT(39.3)| 2024.04.08 |Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity(太空微重力下硫胺素修饰的人多能干细胞来源的心肌细胞的代谢重编程) 在太空飞行期间,心...
Mol. Cell, 6 (2000), pp. 269-279 View PDFView articleGoogle Scholar Dringen et al., 2000 R. Dringen, J.M. Gutterer, J. Hirrlinger Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species Eur. J. Biochem., 267 ...
骨髓间充质干细胞(mesenchymal stromal cell,MSCs)被报道可有效抑制免疫细胞活化,包括T淋巴细胞、B淋巴细胞,巨噬细胞,自然杀伤细胞,DC细胞和其他免疫细胞等。研究结果显示在高脂饮食诱导的NAFLD小鼠模型中移植MSCs,可抑制脾脏CD4+干扰素-γ...
Thus, an improved understanding of the metabolic strategies that enable tissue residency by T cells could inform new approaches to empower immune responses in tissues and solid tumours. Here, to systematically define the basis for the metabolic reprogramming supporting TRM cell differentiation, survival ...