Metabolism in the Tumor Microenvironment: What is Known about Stromal and Immune Cells?Warburg effecttumor cellsmetabolic reprogramming of cancerimmune cellsglutaminolysisglycolysisfibroblastsEndothelial cellsBackground: In the 20th century, cancer metabolism has been studied from different aspects. In the ...
Whatever 'Oumuamua is (almost certainly not made by aliens, in my view), it is a fascinating object and presents lots of interesting scientific questions that will trigger further studies and observations. We will never see 'Oumuamua again, and we may never know exactly what it is. But seein...
Medical textbooks have always taught—and clinical practice correspondingly operates on the supposition—that type 2 diabetes can only “inexorably progress.” The belief is that once a patient with diabetes requires pharmacointervention, the disease is intractable. This long-entrenched dogma is omnipresen...
The impact of chronic mitochondrial dysfunctions is well established in several pathologies including neurodegenerative diseases (such as Alzheimer's and Parkinson's disease), metabolic diseases (such as diabetes and obesity) and cancer [5]. Several cellular signaling pathways are implicated in the ...
But mental distress is not always a function of personality. Resilient people can also be brought to breaking point by the "climate" at work without the control to change it. Bullying takes many forms Safe Work Australia definesworkplace bullyingas repeated and unreasonable behaviours directed towar...
Lactate is also responsible for metabolic reprogramming, inducing inhibition of glycolysis [55]. In addition to promoting an immunopermissive environment by targeting immune cells present in lamina propria, lactate plays a critical role in regulating IECs inflammatory activity. It inhibits the activation ...
[208] discussed how metabolic reprogramming of host cells during lytic viral infection alters the nutrient cycle and ocean exports of carbon. They reported that viral infection transforms host metabolism through metabolic genes encoded by the virus, whose functions appear to alleviate energy and ...
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Reprogramming by nuclear transfer Somatic cell nuclei are introduced into enucleated cells of a different identity. This can erase epigenetic memory and alter the identity of the donor nucleus. H3.3 A variant of histone H3, which is expressed throughout the cell cycle and is incorporated into chro...
Search all BMC articles Search Breast Cancer Research Home About Articles Submission Guidelines Submit manuscript Consistency, now what? Download PDF Download PDF Editorial Open access Published: 21 July 2017 Consistency, now what? Mary Beth Terry1,2 ...