there is little research refer to the lipidomic profile of CAFs. To explore the alternation of lipid metabolism of CAFs and whether it promotes migration of CRC cells, we detected lipid profiling of CAFs and NFs and their CM by using UPLC-Q-TOF/MS based on lipidomic assay. The lipidomic ...
The various pathways involved in the metabolism of lipid, which has the potential to be therapeutic targets, are highlighted. Also, the various driving factors critical for lipid metabolism alterations and the major role played by lipids in cancer and ways of targeting it are critically analyzed....
(tme). lipid reprogramming plays an essential role in the tme. lipids are closely linked to several immune cells and their phenotypic transformation. the reprogramming of tumor lipid metabolism further promotes immunosuppression, which leads to immune escape. this event significantly affects the ...
Metabolic reprogramming has emerged as a critical feature of cancer. To adapt to the hypoxic and nutrient-poor microenvironment, in addition to increasing glucose uptake and aerobic glycolysis, tumor cells also undergo lipid metabolism reprogramming to enhance their biological behaviors [1]. This is ch...
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We propose selective mRNA processing and translation by UHMK1 constitutes a mechanism of non-genetic resistance to targeted therapy in melanoma by controlling metabolic plasticity induced by therapy.Similar content being viewed by others Increased inflammatory lipid metabolism and anaplerotic mitochondrial ...
promoting the immunosuppressive cytokine IL10 in the TME [162]. Concerning the crucial role of lipid metabolism in the TME, serum lipids can predict the efficacy of anti-PD-1 therapy in iCCA patients, with apolipoproteinA-1 (APOA1) and triglycerides (TG) as notable independent predictors [163...
The aim of this review is to assess the metabolic reprogramming processes that intersect with resistance to anticancer therapy, with particular attention given to the changes in glycolysis, lipid metabolism, and amino acid metabolism that accompany this phenomenon. In addition, the role of sEVs in ...
The extraordinary potency and broad antiviral spectrum of AM580 hinted that its cellular target should be a vulnerable and upstream effector. Using AM580 as a tool compound, we try to decipher the key components of lipid metabolism that exhibited broad relevance to human viral infections. First, ...
Leptin, a hormone predominantly derived from adipose tissue, is well known to induce growth of breast cancer cells. However, its underlying mechanisms remain unclear. In this study, we examined the role of reprogramming of lipid metabolism and autophagy in leptin﹊nduced growth of breast cancer ...