Author Correction: metabolic signaling in T cellsImmunologyMolecular biologyAn amendment to this paper has been published and can be accessed via a link at the top of the paper.doi:10.1038/s41422-020-00421-5Justin A. ShyerRichard A. Flavell...
Metabolic signaling in T cells. Cell Res. 30, 649–659 (2020). Article PubMed PubMed Central Google Scholar Sun, S.-C. The non-canonical NF-κB pathway in immunity and inflammation. Nat. Rev. Immunol. 17, 545–558 (2017). Article CAS PubMed PubMed Central Google Scholar Dejardin...
16,17,18,19Themis constitutively interacts with the adaptor protein Grb2 and with the phosphatase Shp1, affecting its activity,15,16,17,18,19,20,21but the precise molecular function of Themis in the regulation of signaling pathways in T cells remains controversial. Themis has been proposed...
2. Cellular metabolism in a nutshell 3. Naïve T cells display a metabolic quiescent phenotype 4. T cell activation requires the orchestration of signaling pathways and metabolic reprogramming 5. Memory T cells—remembering metabolic pathways 6. Regulatory T cells—against the (glycolytic) flow 7....
Table S1. The transcriptome of CD4+ or CD8+ T cells isolated from NT and ES-treated mice, Related to Figures 2A–2D Table S2. PLS-DA of metabolomic profile in the serum of WT and Miga2TKO mice, Related to Figures 4A–4D Table S3. ScRNA-sequencing of the amygdala from WT mice, Rel...
T cell killing assaysare used to examine the effect of test compounds on immune cell-mediated killing of cultured tumor cells. Cytotoxic T cells are a class of T cells that recognize and destroy virus-infected cells and tumor cells. In the T cell killing assay, target tumor cells are first...
Bomfim, T. R. et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers.J. Clin. Invest.122, 1339–1353 (2012). ArticleCASPubMedPubMed CentralGoogle Scholar ...
Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in the late stages of cancer. Once cancer cells are generated, TGF-β signaling is r
active in various osteoblast and osteoblast precursor cell lines, and can promote bone formation when activated in these cells [28,29] (Fig.1). Fig. 1 Canonical and non-canonical Wnt signaling pathways under normal conditions. Abbreviations: APC, adenomatous polyposis; AP-1, activator protein 1...
Cells or samples were divided into high- and low-score subgroups in terms of the median value of R-loop scores. Analysis of cell–cell interaction and cytokine signaling activity Clustering analysis was conducted according to the integrated joint embedding generated by Harmony with the Louvain ...