CELL metabolismTUMORST cellsADENOSYLMETHIONINET-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in cancer, but how tumor cells drive T-cell exhaustion remains elusive. Here, we find T-cell exhaustion linked to overall survival in 675 hepatocellular carcinoma (HCC) ...
Current immunotherapies yield remarkable clinical outcomes by boosting the power of host immunity in cancer cell elimination and viral clearance. However, after prolonged antigen exposure, CD8+ T cells differentiate into a special differentiation state k
过继性T细胞疗法(Adoptive T Cell Therapy,ACT)是一种个性化的免疫治疗方法,能够通过将患者体外扩增或修饰的T细胞重新输回体内来增强免疫系统对抗癌症的能力,从而更精准有效地清除癌细胞。然而,过继性T细胞疗法在治疗血液系统恶性肿瘤中效果显著,...
Chestnut Studying 摘要 The efficacy of chimeric antigen receptor (CAR) T cell therapy is hampered by relapse in hematologic malignancies and by hyporesponsiveness in solid tumors. Long-lived memory …
2023 年 1 月 30 日,中国医学科学院系统医学研究院/苏州系统医学研究所(简称「系统所」)李贵登/张连军团队与四川大学华西第二医院陈路团队合作在Nature Metabolism杂志上发表了题为Extracellular acidosis restricts one-carbon metabolism and ...
The fundamental changes in metabolism, regulation, epigenetic control, and reversibility of T cell exhaustion need further elucidation to enable development of new therapeutic approaches and support the use of existing therapies in rational combinations. Improved understanding may also allow us to ask—and...
CAR T cells bearing an HVEM-derived CSSD display the greater effector function than those with CD28- or 4-1BB-derived CSSD, which may be due to the reduced T cell exhaustion, reprogrammed energy metabolism and balanced differentiation of memory T cell subsets [51]. Toll-like receptor 2 (...
While our finding demonstrates that tumor-derived cholesterol induces tumor-infiltrating CD8+ T cell exhaustion, this work does have some limitations. ER stress was induced by cholesterol, but how cholesterol disrupts lipid metabolism and induces ER stress in CD8+ T cells is unclear. XBP-1 upregul...
It has become clear that tight control of cellular metabolism is crucial for almost every step of Tcell activation[1]. Metabolic processes ensure that T cells sustain the increased energy needs that are associated with a protective immune response. Especially the environment, for example the tumor...
as a possible culprit in the immune response associated with allergic reaction, known as the Th2 response. "The research suggests a possible new therapeutic approach to autoimmune disorders that would be designed to boost the function of regulatory T cells by modulating cell metabolism," Chi said...