Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b.doi:10.1016/S1074-7613(00)80449-5Fas/APO-1(CD95) ligation activates programmed cell death, a cellular process that plays an important role in the maturation of the host immune response...
we hypothesized that SARS-CoV-2 infection-mediated lymphopenia could also be related to T cell apoptosis. By comparing intensive care unit (ICU) and non-ICU COVID-19 patients with age-matched healthy donors, we found a strong
Our results showed that JNK and p73 pathway are activated when facing DNA damage, leading to rapid cell apoptosis. In this context, p53 may not be a major player in preventing the malignant proliferation of T cells, different from its well-known function in suppressing tumorigenesis. Indeed, ...
Once the antigen load is reduced, the lack of stimulus for Teff cells leads to their apoptosis [1], except for a small number of cells that become memory T cells [2], [3]. Without permanent antigen stimulation, a memory T cell has – similar to a naïve T cell – much lower ...
d) FAS ligand expressed by γδ T cells, when exposed to FAS receptor available on influenza-infected cells surface activates the pathway of FAS-FASL apoptosis to destroy the infected cell Full size image Table 2 Anti-influenza mechanisms of γδ T cells in the respiratory tract Full size ...
In addition, CTLs contribute to the apoptosis of tumor cells through the Fas/FasL pathway and suppress tumors by inducing ferroptosis and pyroptosis 14. Dead tumor cells release additional tumor antigens and thereby amplify the T-cell response ...
cell lines showed a significantly higher sensitivity to HHT (IC50: 5-10ng/mL) than Loucy cells (IC50: 57.07ng/mL) after 24 hours’ treatment, with a dose-dependent reduction of viability, increase in apoptosis, cell cy...
T cell apoptosis is associated with defective cell-mediated effector functions in several infectious diseases. In tuberculosis, there is evidence that T ce... GT Seah,GAW Rook - 《Journal of Immunology》 被引量: 125发表: 2001年 Human CD30+ cells are induced by Mycobacterium tuberculosis and pr...
Cell cycle and apoptosis regulation by NFAT transcription factors :new roles for an old player[J]. Cell Death Dis,2016,7 :e2199. [3] Lopez-Rodríguez C,Aramburu J,Rakeman AS,et al. NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun[J]. Proc Natl ...
Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be...