Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. The mechanism of apoptosis is complex and involves many pathways. Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, ...
M. Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancer. Clin. Cancer Res. 20, 2516–2522 (2014). Article CAS PubMed PubMed Central Google Scholar Meng, J. et al. Apoptosis induction by MEK inhibition in human lung ...
Targeting Survivin in Cancer Therapy: Pre-clinical Studies Survivin is a structurally unique member of the inhibitor of apoptosis protein (IAP) family that acts as a suppressor of apoptosis and plays a central role... M Pennati,M Folini,N Zaffaroni - Springer Netherlands 被引量: 645发表: 2009...
Apoptosis&CancerApoptosis&CancerApoptosis&CancerApoptosis&Cancer Apoptosisisamulti-step,multi-pathwaycell- deathprogramthatisinherentineverycellof thebody.Incancer,theapoptosis:cell-division ratioisaltered,whichresultsinanetgainof malignanttissue. ——由基因控制的自主性有序死亡,亦称程序性死亡. I-1.Apoptosis...
Background Parthenolide (PTL) is a sesquiterpene lactone which can induce apoptosis in cancer cells and eradicate cancer stem cells such as leukemia stem cells, prostate tumor-initiating cells and so on. However, the mechanism remains largely unclear. Methods Lung cancer cells were treated with part...
Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev. 2008;19:325–31. Article CAS PubMed Google Scholar Li H, Zhu H, Xu C-j, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998;94:491–501. ...
Klas G. WimanWiley‐VCH Verlag GmbHStridh, H., Bykov, V. J. N., Selivanova, G., and Wiman, K. G. (2006). Cancer therapy by reactivation of the p53 apoptosis pathway. In "Apoptosis and Cancer Therapy" (K.‐M. Debatin and S. Fulda, Eds.), Vol. 2, pp. 891-912. Wiley‐...
The present study provides evidence that nicotine (a) activates the mitogen-activated protein (MAP) kinase signalling pathway in lung cancer cells, specifically extracellular signal-regulated kinase (ERK2), resulting in increased expression of the bcl-2 protein and inhibition of apoptosis in these ...
Fig. 2. Effects of auransterol on intrinsic-apoptosis pathway in HT-29 colon cancer cells, (A) Effects on mitochondrial transmembrane potential (MTP). (B) Effects on overproduction of reactive oxygen species (ROS). (C) Cyt c, (D) BAX, (E) Bcl-2, and (D) cleaved PARP-1 protein lev...
Role of H2S in the apoptotic pathway of ER stress: In cervical cancer cell line Hela, morpholin-4-ium 4-methoxyphenyl(morpholino) phosphinodithioate (GYY4137), a slow-releasing H2S donor induces apoptosis by stimulating ER stress, causing up-regulation of IP3R1 and IP3R2 expression on the ER...