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Protein aggregation and mitochondrial dysfunction are two central pathogenic processes in both familial and sporadic Parkinson’s disease (PD). However, the way in which these two processes converge to cause neurodegeneration is unknown. Missense mutations1,2, and duplications or triplications of theSNC...
Alpha synuclein (αS) is a ~14 kDa intrinsically disordered protein. Decades of research have increased our knowledge on αS yet its physiological function remains largely elusive. The conversion of monomeric αS into oligomers and amyloid fibrils is believed to play a central role of the path...
Kahle P. J., Neumann M., Ozmen L., and Haass C. (2000) Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson’s disease-associated protein.Ann. N.Y. Acad. Sci.920, 33–41. ArticlePubMedCASGoogle Scholar Kholodilov N. G., ...
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Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes 2008, Dementia and Geriatric Cognitive Disorders Inclusion body formation and neurodegeneration are parkin independent in a mouse model of α-synucleinopathy ...
The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci. 1, 426–471. https://doi.org/10.1002/pro....
Alpha-synuclein is a neuronal protein thought to be central in the pathogenesis of Parkinson's disease (PD) because it comprises the fibrillar core of Lewy bodies, one of the histologically defining lesions of PD, and because mutations in alpha-synuclein cause autosomal dominant PD. Although its...
Monomeric alpha-synuclein (aSyn) is a well characterised protein that importantly binds to lipids. aSyn monomers assemble into amyloid fibrils which are localised to lipids and organelles in insoluble structures found in Parkinson’s disease patient’s brains. Previous work to address pathological aSyn...
Fig. 5.Shows alpha-synuclein (ASNC) level in the cerebrospinal fluid (CSF pg/μL), substantia nigra pars compacta (SNpC, ng/μg) and Striatum (STr, ng/μg) of control, MTPP induced Parkinson's disease (PD) alone or PD with concussive head injury (CHI) induced mild traumatic brain...