2001 . Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia . Brain Res 898 : 181 – 185 .Kitamura Y, Ishida Y, Takata K, et al. Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia[J]. Brain ...
帕金森病(Parkinson disease,PD)是最常见的神经退行性运动障碍疾病,其病理上以多巴胺神经元的丢失和黑质致密部存活神经元胞质内包含体-路易小体(Lewy bodies,LBs)为特征,并伴有营养缺陷型神经突-路易神经突(Lewy neuritis,LNs)。虽然围绕路易小体的研究有很多,但是对其生成的机制仍不甚清楚。Alpha-synuclein(α-syn...
The increase of a protein called alpha-synuclein in the brain has long been considered the fundamental cause of Parkinson’s (帕金森病). This leads to the reduced production of dopamine (多巴胺), which helps control muscle movement. While some existing treatments aim to ease these symptoms by ...
Neurodegeneration in PD is accompanied by the appearance of intraneuronal protein aggregates, denoted Lewy bodies (LBs).3Interestingly, also LB pathology is initially found in the distal axons before becoming evident in the neuronal somata, and dystrophic neurites, so called 'Lewy neurites', outnu...
alpha-Synuclein known as a natively unfolded protein has self-assembled into the ordered protein aggregates of amyloid fibrils which comprise the radiating filaments found in Lewy bodies. Amyloid fibrils are generated via either a template-dependent or template-independent mechanism. The prevalent ...
The presence of aggregated alpha-synuclein molecules is a common denominator in a variety of neurodegenerative disorders. Here, we show that alpha-synuclein (alpha-syn) is an outstanding substrate for the protein tyrosine kinase p72syk (Syk), which phosphorylates three tyrosyl residues in its C-ter...
Keywords: Alpha-synuclein, Parkinson's disease, Neuropathic pain, Nociception, Protein aggregation Introduction Parkinson's disease (PD) is traditionally considered a neurodegenerative motor disorder, but it is becom- ing increasingly clear that non-motor symptoms also adversely impact the quality of...
The meaning of ALPHA-SYNUCLEIN is a protein that is found primarily in neurons and accumulates to form Lewy bodies in people affected with Parkinson's disease and some forms of dementia. How to use alpha-synuclein in a sentence.
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Methods:Mass spectrometry was used to determine the specificity of antibody α-synuclein (211) for α-synuclein. Using gel electrophoresis we measured protein levels detected by α-synuclein specific antibodies in the cerebrospinal fluid (CSF) of DLB patients and compared them to age matched controls...