Peptides: Design, synthesis and biological activityNo abstract is available for this article.doi:10.1016/S0014-5793(95)90815-3John D. WadeFEBS Letters
Selected peptide ester derivatives were further hydrolyzed by using lithium hydroxide (LiOH) to afford the corresponding acid derivatives 5ba-da and 6e(a)-g(a). All peptide derivatives were assayed for antimicrobial and anthelmintic activities against eight pathogenic microbes and three earthworm ...
Two well-known examples of these types of amino acids are 3,4-dihydroxy-l-phenylalanine (l-DOPA) and l-thyroxine, which are both produced in humans. A number of nonribosomal peptides containing unusual amino acids have also been isolated from microorganisms, such as bacteria and fungi. ...
Synthesis and biological activity of peptidyl derivatives o... As an approach to the development of antimicrobial agents, a novel peptide carrier system was designed, based on the chemical instability of alpha-substitu... WD Kingsbury,JC Boehm,RJ Mehta,... - 《Journal of Medicinal Chemistry》 ...
By mis-acylating tRNAfMet, we and others have shown that protein synthesis can be initiated with a variety of canonical and noncanonical amino acids both in vitro and in vivo. Furthermore, because the α-amine of the initiating amino acid is not required for peptide bond formation, ...
is chemically bound to an insoluble material and reagents are added in the solution-phase. Excess reagents can be easily removed, and purification achieved, by washing. Solid-phase methods are widely used for the synthesis of biological molecules such as peptides, nucleic acids and oligosaccharides...
Cyclodipeptide oxidases are filamentous enzymes. Here, the authors dissect the mechanism of a promiscuous flavoenzyme from the biosynthesis of cyclodipeptide natural products, unveiling fast catalysis for peptide oxidation in a distinct active site. ...
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All derivatives exhibited higher binding affinity in μ-opioid receptor system than the selective peptide ligand DAMGO (Fig. 1A), some of them had extremely low Ki values (Table 1). For DOR the ligands showed comparable binding affinities than the selective DOR agonist Ile5,6-deltorphin II ...
Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists Author links open overlay panelMonika Maciuszek a b, Almudena Ortega-Gomez c, Sanne L. Maas c, Jose Garrido-Mesa b, Bartolo Ferraro c, Mauro Perretti b, Andy Merritt a, Gerry...