Methods such as solid-phase peptide synthesis (SPPS), native chemical ligation, and α-ketoacid hydroxylamine ligation are discussed. SPPS, for instance, has emerged as a powerful and efficient technique for the chemical synthesis of peptides. Due to the advent of new tools like SPPS and ...
Chemical Synthesis of Peptide Libraries. Bioorg. Med. Chem. Lett. 1993, 3, 413-418.Sebestyen F , Dibo G , Kovacs A , Furka A ( 1993 ): Chemical synthesis of peptide libraries . Bioorg Med Chem Lett 3 : 413 – 418 .Sebestyen, F., Dibo, G., Kovacs, A., Furka, A.; ...
For the proteins that cannot be expressed exactly by cell expression technology (e.g., proteins with multiple posttranslational modifications or toxic proteins), chemical synthesis is an important substitute. Given the limited peptide length offered by solid-phase peptide synthesis invented by Professor...
Chemical Synthesis of Peptides and Proteins This review article provides a critical perspective on the current status of the methods of chemical peptide synthesis actually used in the research labora... SBH Kent - 《Annual Review of Biochemistry》 被引量: 992发表: 1988年 Chemical Synthesis of Pep...
Chemical synthesis of the nucleotidyl peptides. This work aims at developing a strategy to synthesize functional cyclic copolyesters,based on the living ring-opening polymerization and the intra-molecula... Y Ueno,R Saito,H Hotoda,... - 《Acta Polymerica Sinica》 被引量: 0发表: 2013年 Chemo...
PeptidesGuidelines for submitting commentsPolicy: Comments that contribute to the discussion of the article will be posted within approximately three business days. We do not accept anonymous comments. Please include your email address; the address will not be displayed in the posted comment. Cell ...
Yet the many undesirable properties of peptides as drugs, such as poor oral availability and low in vivo stability, have prompted chemists to develop methods for the efficient synthesis of conformationally constrained peptide, biopolymer and non-polymeric compound collections....
efforts since the 1960s, the chemical synthesis of P3HB with isotacticityPm(defined as the probability ofmesolinkages between monomer units) >0.85 from the ROP ofrac-β-BL has proven elusive. For example, the ROP ofrac-β-BL by alkyl aluminoxanes produced a mixture of iso-enriched P3HB ...
Chemical synthesis occurs when two or more molecules are combined to form a product molecule that possesses specific properties.
synthesis of these biomolecules is economically less feasible for large-scale applications, and hence biological production seems to be the only realistic alternative. Similar content being viewed by others Discovery and biosynthesis of tricyclic copper-binding ribosomal peptides containing histidine-to-buty...